Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.35 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL594110 | 0.91 | SMN1; SMN2 (0.36) | SMN1; SMN2MAPK1LMNAALDH1A1TSHR | |
| SCHEMBL20624957 | 0.82 | SMN1; SMN2 (0.43) | SMN1; SMN2MAPK1LMNAALDH1A1TSHR | |
| SCHEMBL3493673 | 0.78 | TP53 (0.35) | MAPK1LMNAL3MBTL1 | |
| SCHEMBL15996143 | 0.75 | ALDH1A1 (0.40) | SMN1; SMN2MAPK1LMNAALDH1A1TSHR | |
| SCHEMBL25929815 | 0.75 | CTSS (0.40) | SMN1; SMN2MAPK1LMNAALDH1A1TSHR | |
| SCHEMBL15069494 | 0.74 | MAPK1 (0.44) | SMN1; SMN2MAPK1LMNAALDH1A1TSHR | |
| SCHEMBL2203295 | 0.73 | LMNA (0.41) | SMN1; SMN2MAPK1LMNAALDH1A1TSHR | |
| SCHEMBL347049 | 0.73 | TSHR (0.41) | MAPK1LMNAALDH1A1TSHRL3MBTL1 | |
| SCHEMBL5618 | 0.70 | CYP3A4 (0.49) | SMN1; SMN2MAPK1LMNAALDH1A1POLB | |
| SCHEMBL594661 | 0.69 | ALDH1A1 (0.38) | SMN1; SMN2MAPK1LMNAALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2448942-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | Schering Corporation (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-2417138-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | Schering Corporation (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2011002887-A1 | FUSED TRICYCLIC COMPOUNDS AS NOVEL mTOR INHIBITORS | SCHERING CORPORATION (US) | 2011-01-06 | — | — | WO | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |