Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 1/20 | 0.70 |
| ▸ | CASP6 | P55212 | 1/20 | 0.70 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.70 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.52 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 7/20 | 0.47 |
| ▸ | NPC1 | O15118 | 6/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5950203 | 0.84 | KMT2A (0.67) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL23509616 | 0.83 | RAB9A (0.64) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL19473756 | 0.83 | RAB9A (0.64) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL19473737 | 0.83 | RAB9A (0.64) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL6083625 | 0.83 | PKM (0.68) | TDP1APEX1RAB9ANPC1MEN1 | |
| SCHEMBL19473738 | 0.82 | RAB9A (0.67) | RAB9ANPC1MEN1KMT2AEPHX1 | |
| SCHEMBL23509611 | 0.82 | RAB9A (0.67) | RAB9ANPC1MEN1KMT2AEPHX1 | |
| SCHEMBL19473762 | 0.81 | KMT2A (0.60) | HCRTR1HCRTR2RAB9ANPC1MEN1 | |
| SCHEMBL11929841 | 0.79 | RAB9A (0.58) | GRK2CASP6CASP8CTDSP1TDP1 | |
| SCHEMBL19473763 | 0.75 | EPHX1 (0.51) | RAB9ANPC1MEN1KMT2AEPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | US | claimed |
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | NEUROSEARCH A/S (DK) | 2006-07-20 | — | — | US | disclosed |
| EP-1537075-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2005-06-08 | — | — | EP | disclosed |
| WO-2004022529-A2 | DIARYLUREA DERIVATIVES AND THEIR USE AS CHLORIDE CHANNEL BLOCKERS | NEUROSEARCH A/S (DK) | 2004-03-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060160856-A1 | Diarylurea derivatives and their use as chloride channel blockers | KIT, ORAI1, CACNA1C | GRK2 1009/4885CASP6 2550/4885CASP8 2814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.