SCHEMBL5950754

SCHEMBL5950754

CN(C)c1ccc(C=C(C#N)C(=O)O)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.71
MAPT P10636 2/20 0.71
KMT2A Q03164 2/20 0.71
ALDH1A1 P00352 2/20 0.71
CISD1 Q9NZ45 1/20 0.65
KDM4E B2RXH2 1/20 0.65
SLC16A3 O15427 1/20 0.65
CYP3A4 P08684 1/20 0.65
HPGD P15428 1/20 0.65
SLC16A1 P53985 1/20 0.65
GPR35 Q9HC97 1/20 0.65
EGFR P00533 1/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16544440 1.00 MEN1 (0.71) MEN1MAPTKMT2AALDH1A1CISD1
SCHEMBL5950751 1.00 MEN1 (0.71) MEN1MAPTKMT2AALDH1A1CISD1
SCHEMBL15129044 0.95 MEN1 (0.66) MEN1MAPTKMT2AALDH1A1CISD1
SCHEMBL15129043 0.95 MEN1 (0.66) MEN1MAPTKMT2AALDH1A1CISD1
SCHEMBL11941273 0.95 MEN1 (0.66) MEN1MAPTKMT2AALDH1A1CISD1
SCHEMBL9820289 0.90 CISD1 (0.65) ALDH1A1CISD1KDM4ESLC16A3CYP3A4
SCHEMBL15521643 0.87 KMT2A (0.67) MEN1MAPTKMT2AALDH1A1
SCHEMBL29502532 0.86 CISD1 (0.69) ALDH1A1CISD1KDM4ESLC16A3CYP3A4
SCHEMBL12639966 0.86 CISD1 (0.69) ALDH1A1CISD1KDM4ESLC16A3CYP3A4
SCHEMBL12672953 0.86 CISD1 (0.69) ALDH1A1CISD1KDM4ESLC16A3CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12365830-B2 Ligand-exchangeable janus nanoparticles and methods of making the same ALLIANCE FOR SUSTAINABLE ENERGY, LLC (US) 2025-07-22 US claimed
US-20220259490-A1 LIGAND-EXCHANGEABLE JANUS NANOPARTICLES AND METHODS OF MAKING THE SAME Alliance for Energy Innovation, LLC 2022-08-18 US claimed
WO-2020252075-A1 LIGAND-EXCHANGEABLE JANUS NANOPARTICLES AND METHODS OF MAKING THE SAME ALLIANCE FOR SUSTAINABLE ENERGY, LLC (US) 2020-12-17 WO claimed
US-10544168-B2 Ligand-exchangeable nanoparticles and methods of making the same ALLIANCE FOR SUSTAINABLE ENERGY, LLC (US) 2020-01-28 US claimed
US-20170362255-A1 LIGAND-EXCHANGEABLE NANOPARTICLES AND METHODS OF MAKING THE SAME Alliance for Energy Innovation, LLC 2017-12-21 US claimed
US-20160168083-A1 THERAPEUTIC COMPOUNDS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2016-06-16 US claimed
US-20140371272-A1 THERAPEUTIC COMPOUNDS THE GOVERNMENT OF THE UNITED STATES, AS REPRESENTED BY THE SECRETARY OF THE ARMY 2014-12-18 US claimed
EP-2804852-A2 THERAPEUTIC COMPOUNDS Regents Of The University Of Minnesota (US) 2014-11-26 EP claimed
WO-2013109972-A2 THERAPEUTIC COMPOUNDS REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 2013-07-25 WO claimed
US-20060084176-A1 Detection of uronium salts YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM (IL) 2006-04-20 US claimed
US-12365830-B2 Ligand-exchangeable janus nanoparticles and methods of making the same ALLIANCE FOR SUSTAINABLE ENERGY, LLC (US) 2025-07-22 US disclosed
CN-114507158-B Pleuromutilin alpha-cyano cinnamic acid ester compounds with drug-resistant bacteria resisting activity and preparation method and application thereof 广东医科大学附属医院 2023-04-28 CN disclosed
US-20220259490-A1 LIGAND-EXCHANGEABLE JANUS NANOPARTICLES AND METHODS OF MAKING THE SAME Alliance for Energy Innovation, LLC 2022-08-18 US disclosed
CN-114507158-A Pleuromutilin alpha-cyano cinnamate compounds with drug-resistant bacterium resisting activity and preparation method and application thereof 广东医科大学附属医院 2022-05-17 CN disclosed
WO-2020252075-A1 LIGAND-EXCHANGEABLE JANUS NANOPARTICLES AND METHODS OF MAKING THE SAME ALLIANCE FOR SUSTAINABLE ENERGY, LLC (US) 2020-12-17 WO disclosed
EP-0335641-B1 Organic nonlinear optical substance TEIJIN LTD (JP) 1994-01-05 EP disclosed
US-5196147-A Optical crystals TEIJIN LIMITED (JP) 1993-03-23 US disclosed
EP-0335641-A2 Organic nonlinear optical substance TEIJIN LIMITED (JP) 1989-10-04 EP disclosed
US-4284621-A SUNSCREEN FOR SKIN BAYER AKTIENGESELLSCHAFT (DE) 1981-08-18 US disclosed
US-4017486-A Cationic alpha-cyano-p-dimethylaminocinnamoyl dyes and paper dyed therewith AMERICAN CYANAMID COMPANY (US) 1977-04-12 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140371272-A1 THERAPEUTIC COMPOUNDS HLA-DRB1, SLC10A1, NFATC1 MEN1 28/4885MAPT 3241/4885KMT2A 3448/4885
US-10544168-B2 Ligand-exchangeable nanoparticles and methods of making the same CA6, CA13, EPCAM MEN1 2469/4885MAPT 2354/4885KMT2A 2760/4885
US-20160168083-A1 THERAPEUTIC COMPOUNDS HLA-DRB1, SLC10A1, NFATC1 MEN1 30/4885MAPT 3327/4885KMT2A 3288/4885
US-20170362255-A1 LIGAND-EXCHANGEABLE NANOPARTICLES AND METHODS OF MAKING THE SAME CA6, CA13, EPCAM MEN1 2469/4885MAPT 2354/4885KMT2A 2760/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.