Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3849356 | 0.89 | CXCR2 (1.00) | CXCR2CCR7 | |
| SCHEMBL3849366 | 0.89 | CXCR2 (1.00) | CXCR2CCR7 | |
| SCHEMBL3850612 | 0.89 | CXCR2 (1.00) | CXCR2CCR7 | |
| SCHEMBL3850313 | 0.88 | CXCR2 (0.98) | CXCR2CCR7 | |
| SCHEMBL3850323 | 0.88 | CXCR2 (0.98) | CXCR2CCR7 | |
| SCHEMBL6360635 | 0.84 | CXCR2 (0.75) | CXCR2CCR7 | |
| SCHEMBL5190682 | 0.83 | CXCR2 (0.76) | CXCR2CCR7 | |
| SCHEMBL3850177 | 0.82 | CXCR2 (0.77) | CXCR2CCR7 | |
| SCHEMBL3859363 | 0.81 | CXCR2 (0.86) | CXCR2CCR7 | |
| SCHEMBL5498108 | 0.81 | CXCR2 (1.00) | CXCR2CCR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060111569-A1 | Thiazolopyrimidines and their use as modulators of chemokine receptor activity | BONNERT ROGER | 2006-05-25 | — | — | US | claimed |
| US-6949643-B2 | Thiazolopytimidines and their use as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2005-09-27 | — | — | US | claimed |
| EP-1385854-B1 | THIAZOLOPYRIMIDINES AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2005-02-09 | — | — | EP | claimed |
| US-20040157853-A1 | Thiazolopytimidines and their use as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2004-08-12 | — | — | US | claimed |
| US-20060111569-A1 | Thiazolopyrimidines and their use as modulators of chemokine receptor activity | BONNERT ROGER | 2006-05-25 | — | — | US | disclosed |
| US-6949643-B2 | Thiazolopytimidines and their use as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2005-09-27 | — | — | US | disclosed |
| EP-1385854-B1 | THIAZOLOPYRIMIDINES AND THEIR USE AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY | ASTRAZENECA AB (SE) | 2005-02-09 | — | — | EP | disclosed |
| US-20040157853-A1 | Thiazolopytimidines and their use as modulators of chemokine receptor activity | ASTRAZENECA AB (SE) | 2004-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111569-A1 | Thiazolopyrimidines and their use as modulators of chemokine receptor activity | CXCR2, CCR5, CXCR1 | CXCR2 1/4885CCR7 16/4885 |
| US-20040157853-A1 | Thiazolopytimidines and their use as modulators of chemokine receptor activity | CCR5, CCR2, CX3CR1 | CXCR2 5/4885CCR7 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.