Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1149314 | 0.98 | TSHR (0.59) | KMT2AHCAR2TSHRLMNANPC1 | |
| SCHEMBL5079536 | 0.97 | HCAR2 (0.58) | KMT2AHCAR2TSHRLMNANPC1 | |
| SCHEMBL7420866 | 0.90 | HCAR2 (0.50) | KMT2AHCAR2TSHRLMNANPC1 | |
| SCHEMBL7421094 | 0.88 | TSHR (0.51) | KMT2AHCAR2TSHRLMNANPC1 | |
| SCHEMBL20541441 | 0.84 | KDM4E (0.43) | KMT2AHCAR2TSHRNPC1RAB9A | |
| SCHEMBL23909039 | 0.83 | POLB (0.54) | KMT2ATSHRLMNARAB9AGAA | |
| SCHEMBL1007395 | 0.82 | HCAR2 (0.64) | KMT2AHCAR2TSHRLMNANPC1 | |
| SCHEMBL13935666 | 0.82 | POLB (0.46) | KMT2AHCAR2TSHRLMNAKDM4E | |
| SCHEMBL21995909 | 0.82 | POLB (0.46) | KMT2AHCAR2TSHRLMNAKDM4E | |
| SCHEMBL12499437 | 0.81 | KDM4E (0.48) | KMT2ATSHRLMNANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 75 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12576087-B2 | Aryloxypiperidine pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors | MERCK SHARP & DOHME LLC (US) | 2026-03-17 | — | — | US | disclosed |
| US-12264134-B2 | Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | MERCK SHARP & DOHME LLC (US) | 2025-04-01 | — | — | US | disclosed |
| EP-3867232-B1 | NOVEL ARYLALKYL PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-12-18 | — | — | EP | disclosed |
| US-12152019-B2 | Arylalkyl pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors | MERCK SHARP & DOHME LLC (US) | 2024-11-26 | — | — | US | disclosed |
| EP-3886845-B1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-09-04 | — | — | EP | disclosed |
| CN-118026999-A | Indazole hydrazide compound and application thereof in preparation of medicines for treating cancers | 北京大学第一医院 | 2024-05-14 | — | — | CN | disclosed |
| CN-117693502-A | Compounds for inhibiting or degrading ITK, compositions comprising the same, methods of making the same, and methods of using the same | 纽力克斯治疗公司 | 2024-03-12 | — | — | CN | disclosed |
| US-20230097420-A1 | INDAZOLE HYDRAZIDE COMPOUND AND APPLICATION THEREOF | PEKING UNIVERSITY FIRST HOSPITAL (CN) | 2023-03-30 | — | — | US | disclosed |
| EP-3840747-B1 | NOVEL ARYLOXYPIPERIDINE PYRAZOLE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-03-29 | — | — | EP | disclosed |
| US-20230008022-A1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2023-01-12 | — | — | US | disclosed |
| US-6069152-A | NERVOUS SYSTEM DISORDERS; CARDIOVASCULAR DISORDERS; GASTROINTESTINAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-05-30 | — | — | US | disclosed |
| US-5959121-A | Process for preparing 3-substituted indazoles | ELI LILLY AND COMPANY (US) | 1999-09-28 | — | — | US | disclosed |
| US-5914405-A | Process for preparing 3-substituted indazoles | ELI LILLY AND COMPANY (US) | 1999-06-22 | — | — | US | disclosed |
| WO-1999017772-A1 | 5HT4 AGONISTS AND ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |
| WO-1999018080-A1 | PROCESS FOR PREPARING 3-SUBSTITUTED INDAZOLES | ELI LILLY AND COMPANY (US) | 1999-04-15 | — | — | WO | disclosed |
| EP-0908459-A1 | 5-HT4 Agonists and antagonists | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0908452-A2 | Process for preparing 3-substituted indazoles | ELI LILLY AND COMPANY (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5859007-A | TREATMENT OF DIABETES, OBESITY | GLAXO WELLCOME INC. (US) | 1999-01-12 | — | — | US | disclosed |
| EP-0755384-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1997-01-29 | — | — | EP | disclosed |
| WO-1995028391-A1 | CCK OR GASTRIN MODULATING 1,5 BENZODIAZEPINES DERIVATIVES | GLAXO WELLCOME INC. (US) | 1995-10-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12152019-B2 | Arylalkyl pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors | IDO1, IDO2, AADAC | KMT2A 1424/4885HCAR2 515/4885TSHR 3652/4885 |
| US-12576087-B2 | Aryloxypiperidine pyrazole compounds as indoleamine 2,3-dioxygenase inhibitors | IDO1, IDO2, TPH1 | KMT2A 1603/4885HCAR2 317/4885TSHR 1080/4885 |
| US-20230008022-A1 | NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS | IDO1, IDO2, KYNU | KMT2A 520/4885HCAR2 247/4885TSHR 3557/4885 |
| US-12264134-B2 | Substituted piperazine amide compounds as indoleamine 2,3-dioxygenase (IDO) inhibitors | IDO1, IDO2, AADAC | KMT2A 567/4885HCAR2 351/4885TSHR 3608/4885 |
| US-20230097420-A1 | INDAZOLE HYDRAZIDE COMPOUND AND APPLICATION THEREOF | ITGB3, AR, HDAC3 | KMT2A 1326/4885HCAR2 129/4885TSHR 876/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.