Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 2/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 2/20 | 0.42 |
| ▸ | CES1 | P23141 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21780538 | 0.86 | F2R (0.56) | F2RPKMCES2CES1MAPT | |
| SCHEMBL27583391 | 0.85 | F2R (0.48) | F2RHSP90AB1PKMCES2CES1 | |
| SCHEMBL31573474 | 0.83 | PKM (0.45) | F2RPKMCES2CES1MAPT | |
| SCHEMBL30195364 | 0.83 | PTPN1 (0.52) | F2RPKMCES2CES1MAPT | |
| SCHEMBL615669 | 0.83 | PTPN1 (0.52) | F2RPKMCES2CES1MAPT | |
| SCHEMBL27560772 | 0.82 | NPC1 (0.44) | HSP90AB1PKMMAPTKCNH2ALDH1A1 | |
| SCHEMBL196379 | 0.81 | CES2 (0.61) | HSP90AB1PKMCES2CES1KCNH2 | |
| SCHEMBL6174178 | 0.81 | HSP90AB1 (0.48) | HSP90AB1CES2MAPTPOLBALDH1A1 | |
| SCHEMBL29746067 | 0.81 | CES2 (0.61) | HSP90AB1PKMCES2CES1KCNH2 | |
| SCHEMBL31582781 | 0.80 | F2R (0.44) | F2RPKMCES2CES1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 61 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107056673-B | 3, 4-diaryl maleimide derivative and preparation method and application thereof | NANJING TECH UNIVERSITY (CN) | 2019-10-29 | — | — | CN | disclosed |
| CN-106432039-B | 3, 4-diaryl maleimide derivative and preparation method and application thereof | 南京工业大学 | 2019-02-22 | — | — | CN | disclosed |
| CN-108137497-A | Bicyclic derivatives, process for their preparation and pharmaceutical compositions containing them | 法国施维雅药厂 | 2018-06-08 | — | — | CN | disclosed |
| CN-104837844-B | Pyrazole substituted imidazopiperazines as casein kinase 1D/E inhibitors | 百时美施贵宝公司 | 2017-08-29 | — | — | CN | disclosed |
| CN-107056673-A | 3, 4-diaryl maleimide derivative and preparation method and application thereof | 南京工业大学 | 2017-08-18 | — | — | CN | disclosed |
| CN-106946909-A | The nitro imidazole derivatives for the treatment of pulmonery tuberculosis disease | 南京明德新药研发股份有限公司 | 2017-07-14 | — | — | CN | disclosed |
| CN-106232600-A | Dihydroindole 2 ketone and 1,3 pyrrolin also [3,2 c] pyridine 2 ketone derivatives | 豪夫迈·罗氏有限公司 | 2016-12-14 | — | — | CN | disclosed |
| CN-105801571-A | Heterocyclic difluoromethylated oxirane compound and preparation method thereof | 上海大学 | 2016-07-27 | — | — | CN | disclosed |
| CN-105814039-A | Fluorophenyl pyrazole compounds | 伊莱利利公司 | 2016-07-27 | — | — | CN | disclosed |
| CN-103360305-A | Substituted aryl piperazine aralkyl ketone derivative and application of derivative in preparing analgesic | JIANGSU NHWA PHARMACEUTICAL CO LTD | 2013-10-23 | — | — | CN | disclosed |
| CN-1191254-C | Fused pyrrole compounds, pharmaceutical composition containing the same, and the use thereof | MARCKLE GMBH (DE) | 2005-03-02 | — | — | CN | disclosed |
| US-20050033076-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2005-02-10 | — | — | US | disclosed |
| CN-1518550-A | Imidazo [1,2-A] pyridine derivatives for prophylaxis and treatment of herpes viral infections | ʷ��˿�������ȳ�ķ����˾ | 2004-08-04 | — | — | CN | disclosed |
| CN-1418217-A | Fused pyrrole compounds, pharmaceutical composition containing the same, and the use thereof | MARCKLE GMBH (DE) | 2003-05-14 | — | — | CN | disclosed |
| US-20030009046-A1 | Preparation of preparing substituted indanones | EQUISTAR CHEMICALS, LP | 2003-01-09 | — | — | US | disclosed |
| CN-1306511-A | Novel heterocyclic compounds | NOVO NORDISK AS (DK) | 2001-08-01 | — | — | CN | disclosed |
| CN-1254328-A | Process for preparing substituted 2, 3-dihydro-1-indanones | TARGOR GMBH (DE) | 2000-05-24 | — | — | CN | disclosed |
| EP-0968158-A1 | METHOD OF PREPARING SUBSTITUTED INDANONES, THE SUBSTITUTED INDANONES AND METALLOCENES PREPARED THEREFROM | Basell Polyolefine GmbH (DE) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998040331-A1 | PREPARATION OF PREPARING SUBSTITUTED INDANONES | TARGOR GMBH (DE) | 1998-09-17 | — | — | WO | disclosed |
| CN-1115761-A | Derivative, preparation and medical application of quinoline and imidazole | SYNTHELABO (FR) | 1996-01-31 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050033076-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP2J2, IDH3A | F2R 2373/4885HSP90AB1 2881/4885PKM 601/4885 |
| US-20030009046-A1 | Preparation of preparing substituted indanones | CYP1A2, CYP1B1, CYP1A1 | F2R 2214/4885HSP90AB1 2643/4885PKM 703/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.