SCHEMBL5953576

SCHEMBL5953576

COC(=O)C=C(C)C(=O)OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.46
KEAP1 Q14145 1/20 0.46
NFE2L2 Q16236 1/20 0.46
ALDH1A1 P00352 5/20 0.42
SMN1; SMN2 Q16637 1/20 0.35
TSHR P16473 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALOX15 P16050 1/20 0.32
RECQL P46063 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MAPT P10636 3/20 0.31
KDM4E B2RXH2 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31
NFKB1 P19838 1/20 0.30
TET2 Q6N021 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL774085 1.00 HCAR2 (0.46) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL7771274 1.00 HCAR2 (0.46) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
Ammonia Solution, Strong SCHEMBL6291855 0.97 HCAR2 (0.43) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
Ammonia Solution, Strong SCHEMBL21219109 0.97 HCAR2 (0.43) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
Fluoride SCHEMBL28064852 0.97 HCAR2 (0.43) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL9567808 0.97 HCAR2 (0.43) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL7174353 0.87 ALDH1A1 (0.40) HCAR2KEAP1NFE2L2ALDH1A1TSHR
SCHEMBL14225485 0.86 HCAR2 (0.53) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL28058968 0.85 HCAR2 (0.42) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL27360781 0.83 HCAR2 (0.40) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 169 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116143998-A Bio-based hydroxyl-terminated hyperbranched polyester, preparation method thereof and application thereof as plasticizer 上海交通大学 2023-05-23 CN claimed
CN-106770800-B The rapid detection method of 58 kinds of sensitization aromatic in a kind of articles for children 中国检验检疫科学研究院 2019-04-16 CN claimed
CN-106833063-A A kind of wet type electrostatic precipitator vinylite 浙江诺比高分子材料有限公司 2017-06-13 CN claimed
CN-106800624-A A kind of fracture elongation vinylite high and preparation method thereof 浙江诺比高分子材料有限公司 2017-06-06 CN claimed
CN-106770800-A 58 kinds of method for quick of sensitization aromatic in a kind of articles for children 中国检验检疫科学研究院 2017-05-31 CN claimed
CN-103105437-B Method for simultaneous determination of residual quantity of 8 ester allergenic aromatics in toys CHINESE ACAD INSP & QUARANTINE 2014-08-13 CN claimed
CN-103105437-A Method for simultaneous determination of residual quantity of 8 ester allergenic aromatics in toys CHINESE ACAD INSP & QUARANTINE 2013-05-15 CN claimed
US-20260116887-A1 HETEROCYCLIC COMPOUNDS FOR MEDIATING TYROSINE KINASE 2 ACTIVITY GUANGZHOU INNOCARE PHARMA TECH CO LTD (CN) 2026-04-30 US disclosed
EP-4704830-A2 MRGPRX2 INHIBITORS AND METHODS OF USE THEREOF Septerna, Inc. (US) 2026-03-11 EP disclosed
EP-4674894-A2 COPOLYMERS OF N-VINYLPYRROLIDONE WITH FUNCTIONALIZED MALEIC ACID MOIETIES Hemoteq AG (DE) 2026-01-07 EP disclosed
EP-4663688-A2 CROSSLINKERS Hemoteq AG (DE) 2025-12-17 EP disclosed
EP-4656638-A2 PYRAZOLE COMPOUND AND PHARMACEUTICAL USE THEREOF Japan Tobacco Inc. (JP) 2025-12-03 EP disclosed
EP-4584243-B1 CROSSLINKERS HEMOTEQ AG (DE) 2025-11-05 EP disclosed
US-4800216-A ACRYLONITRILE-BUTADIENE-STYRENE BAYER AKTIENGESELLSCHAFT (DE) 1989-01-24 US disclosed
CN-88101916-A Olefin polymerization process and catalyst therefor 1988-10-26 CN disclosed
US-4670163-A HALOHYDROXYALKYLTHIO-SUBSTITUTED OR DIHYDROXYALKYLTHIO-SUBSTITUTED POLYCARBOXYLIC ACIDS AND SALTS PHILLIPS PETROLEUM COMPANY (US) 1987-06-02 US disclosed
US-4383053-A Antifouling paints having fumaric acid ester polymer NIPPON OIL AND FATS CO., LTD. (JP) 1983-05-10 US disclosed
US-4203996-A Synthetic cephalotaxine esters having antileukemic P388 activity THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1980-05-20 US disclosed
US-4152333-A ALKALOIDS THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF AGRICULTURE (US) 1979-05-01 US disclosed
US-4089860-A Preparation of hydantoins by reacting esters of ethylene-1,2-dicarboxylic acids and ureas and thioureas BAYER AKTIENGESELLSCHAFT (DT) 1978-05-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260116887-A1 HETEROCYCLIC COMPOUNDS FOR MEDIATING TYROSINE KINASE 2 ACTIVITY TYK2, JAK2, JAK1 HCAR2 539/4885KEAP1 3418/4885NFE2L2 1738/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.