SCHEMBL774085

SCHEMBL774085

COC(=O)/C=C(/C)C(=O)OC

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 2/20 0.46
KEAP1 Q14145 1/20 0.46
NFE2L2 Q16236 1/20 0.46
ALDH1A1 P00352 5/20 0.42
SMN1; SMN2 Q16637 1/20 0.35
TSHR P16473 2/20 0.33
MEN1 O00255 1/20 0.33
KMT2A Q03164 1/20 0.33
ALOX15 P16050 1/20 0.32
RECQL P46063 1/20 0.32
HSD17B10 Q99714 1/20 0.32
MAPT P10636 3/20 0.31
KDM4E B2RXH2 2/20 0.31
TDP1 Q9NUW8 1/20 0.31
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31
NFKB1 P19838 1/20 0.30
TET2 Q6N021 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7771274 1.00 HCAR2 (0.46) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL5953576 1.00 HCAR2 (0.46) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
Ammonia Solution, Strong SCHEMBL6291855 0.97 HCAR2 (0.43) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
Ammonia Solution, Strong SCHEMBL21219109 0.97 HCAR2 (0.43) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
Fluoride SCHEMBL28064852 0.97 HCAR2 (0.43) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL9567808 0.97 HCAR2 (0.43) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL7174353 0.87 ALDH1A1 (0.40) HCAR2KEAP1NFE2L2ALDH1A1TSHR
SCHEMBL14225485 0.86 HCAR2 (0.53) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL28058968 0.85 HCAR2 (0.42) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2
SCHEMBL27360781 0.83 HCAR2 (0.40) HCAR2KEAP1NFE2L2ALDH1A1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 895 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119118866-A Chain extender containing hydrazide structure, and preparation method and application thereof 美瑞新材料创新中心(山东)有限公司 2024-12-13 CN claimed
EP-3861039-B1 HYDROGEL COMPOSITIONS OPHTALMIC CIE (FR) 2023-11-01 EP claimed
CN-116924964-A Preparation method of tetrahydrocarbazole ring compound 四川轻化工大学 2023-10-24 CN claimed
CN-116143998-A Bio-based hydroxyl-terminated hyperbranched polyester, preparation method thereof and application thereof as plasticizer 上海交通大学 2023-05-23 CN claimed
EP-3861039-A1 HYDROGEL COMPOSITIONS Ophtalmic Compagnie (FR) 2021-08-11 EP claimed
CN-111175411-B Method for determining sensitized aromatics in water color pens and fluorescent pens by microwave-assisted extraction-gas chromatography-mass spectrometry 山东省产品质量检验研究院 2020-09-22 CN claimed
WO-2020070423-A1 HYDROGEL COMPOSITIONS OPHTALMIC COMPAGNIE (FR) 2020-04-09 WO claimed
CN-106770800-B The rapid detection method of 58 kinds of sensitization aromatic in a kind of articles for children 中国检验检疫科学研究院 2019-04-16 CN claimed
CN-108863785-A A kind of low pour point pentaerythritol oleate mixed ester and its synthetic method 湖南理工学院 2018-11-23 CN claimed
CN-106833063-A A kind of wet type electrostatic precipitator vinylite 浙江诺比高分子材料有限公司 2017-06-13 CN claimed
CN-101845157-A Vulcanizable polymer compositions LANXESS DEUTSCHLAND GMBH 2010-09-29 CN claimed
CN-101629005-A Vulcanizable polymer composition LANXESS DEUTSCHLAND GMBH 2010-01-20 CN claimed
US-20090131579-A1 Embedment Casting Composition LUCITE INTERNATIONAL UK LIMITED (GB) 2009-05-21 US claimed
CN-101184816-A Composition for embedment casting LUCITE INT UK LTD (GB) 2008-05-21 CN claimed
EP-1883685-A1 AN EMBEDMENT CASTING COMPOSITION Lucite International UK Limited (GB) 2008-02-06 EP claimed
CN-100339422-C 1, 1-difluoroethylene resin porous film and method for producing same KUREHA CORP (JP) 2007-09-26 CN claimed
WO-2006125976-A1 AN EMBEDMENT CASTING COMPOSITION LUCITE INTERNATIONAL UK LIMITED (GB) 2006-11-30 WO claimed
CN-1774468-A Porous film of vinylidene fluoride resin and method for producing same KUREHA CORP (JP) 2006-05-17 CN claimed
WO-2001077366-A1 POSITIVE SELECTION METHOD, COMPOUNDS, HOST CELLS AND USES THEREOF CUBIST PHARMACEUTICALS, INC. (US) 2001-10-18 WO claimed
US-4665204-A Diester derivatives of tocopherol HENKEL CORPORATION (US) 1987-05-12 US claimed