Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.39 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.39 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.39 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.39 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.37 |
| ▸ | CA2 | P00918 | 4/20 | 0.37 |
| ▸ | CA12 | O43570 | 3/20 | 0.37 |
| ▸ | CA9 | Q16790 | 3/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2187374 | 0.84 | ALDH1A1 (0.34) | CA1CA2CA12CA9POLB | |
| Terephthalic Acid SCHEMBL27908647 | 0.80 | TSHR (0.63) | TSHRTP53ANPEPCA1CA2 | |
| Terephthalic Acid SCHEMBL27908648 | 0.80 | TSHR (0.63) | TSHRTP53ANPEPCA1CA2 | |
| Terephthalic Acid SCHEMBL10796271 | 0.78 | TSHR (0.55) | TSHRTP53ANPEPCA1CA2 | |
| SCHEMBL1905343 | 0.74 | LMNA (0.39) | TP53CA1CA2CA12CA9 | |
| Terephthalic Acid SCHEMBL15167663 | 0.73 | TSHR (0.60) | TSHRTP53ANPEPCA1CA2 | |
| Terephthalic Acid SCHEMBL21351796 | 0.73 | TSHR (0.60) | TSHRTP53ANPEPCA1CA2 | |
| SCHEMBL1232870 | 0.73 | ALDH1A1 (0.41) | HDAC3HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL9503303 | 0.72 | NR4A2 (0.55) | HDAC3HDAC4HDAC1HDAC2HDAC10 | |
| SCHEMBL10789857 | 0.72 | TSHR (0.52) | TSHRTP53ANPEPCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060194708-A1 | Detergents or cleaning agents | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2006-08-31 | — | — | US | disclosed |