Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 2/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 4/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | USP8 | P40818 | 1/20 | 0.48 |
| ▸ | SLC40A1 | Q9NP59 | 3/20 | 0.47 |
| ▸ | NSD2 | O96028 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.45 |
| ▸ | SQSTM1 | Q13501 | 1/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 1/20 | 0.43 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.43 |
| ▸ | BRD1 | O95696 | 1/20 | 0.43 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.43 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5955962 | 0.85 | USP2 (0.57) | PGRKEAP1USP2USP8NFE2L2 | |
| SCHEMBL5955997 | 0.81 | MEN1 (0.58) | PGRKEAP1NFE2L2SQSTM1 | |
| SCHEMBL8752480 | 0.78 | PGR (0.74) | PGRHCRTR1EDNRACYP17A1 | |
| SCHEMBL5956030 | 0.75 | FFAR4 (0.60) | PGRKEAP1NFE2L2SQSTM1TRIM24 | |
| SCHEMBL21708230 | 0.73 | SLC40A1 (0.59) | PGRKEAP1USP2USP8SLC40A1 | |
| SCHEMBL850454 | 0.73 | MRGPRX1 (0.63) | PGR | |
| SCHEMBL5955991 | 0.71 | CKS1B (0.57) | KEAP1SLC40A1NFE2L2SQSTM1TRIM24 | |
| SCHEMBL850766 | 0.71 | PGR (0.54) | PGRACLY | |
| SCHEMBL1339696 | 0.70 | CCR8 (0.60) | PGRKEAP1NSD2HSP90AA1HSP90AB1 | |
| SCHEMBL18434691 | 0.70 | KEAP1 (0.78) | KEAP1SLC40A1NFE2L2SQSTM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-01-05 | — | — | US | claimed |
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM | 2006-01-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060004197-A1 | Sulfonamide-based compounds as protein tyrosine kinase inhibitors | SRC, LCK, ABL1 | PGR 3748/4885KEAP1 1455/4885USP2 1513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.