Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | HPGDS | O60760 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5956923 | 0.97 | F10 (0.57) | F10KMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL5956976 | 0.87 | F10 (0.45) | F10KMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL5956981 | 0.86 | F10 (0.79) | F10MAPT | |
| SCHEMBL3828915 | 0.85 | F10 (0.73) | F10KMT2AMEN1POLBMAPT | |
| SCHEMBL5956966 | 0.84 | F10 (0.44) | F10KMT2AMEN1POLBALDH1A1 | |
| SCHEMBL5956860 | 0.83 | F10 (0.61) | F10KMT2AMEN1SMN1; SMN2POLB | |
| SCHEMBL5956942 | 0.80 | F10 (0.49) | F10KMT2AMEN1KLKB1 | |
| SCHEMBL76312 | 0.77 | F10 (0.65) | F10KMT2AMEN1POLBMAPT | |
| SCHEMBL5956961 | 0.77 | F10 (0.64) | F10KLKB1 | |
| SCHEMBL77682 | 0.77 | F10 (0.84) | F10SMN1; SMN2POLBMAPTKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1633346-B1 | PYRROLIDIN-1, 2- DICARBOXYLIC ACID- 1- (4- ETHINYL- PHENYL) - AMID|- 2- (PHENYL)- AMID| DERIVATIVE AS INHIBITORS OF COAGULATION FACTOR XA AND VIIA FOR THE TREATMENT OF THROMBOSIS | MERCK PATENT GMBH (DE) | 2006-08-23 | — | — | EP | claimed |