Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | DRD4 | P21917 | 10/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5957095 | 1.00 | TSHR (0.48) | TSHRGAADRD4ALDH1A1DRD2 | |
| SCHEMBL7519381 | 0.82 | ALDH1A1 (0.60) | TSHRALDH1A1GLATP53CYP3A4 | |
| SCHEMBL7460830 | 0.82 | ALDH1A1 (0.60) | TSHRALDH1A1GLATP53CYP3A4 | |
| SCHEMBL7054912 | 0.82 | ALDH1A1 (0.60) | TSHRALDH1A1GLATP53CYP3A4 | |
| SCHEMBL31384189 | 0.82 | ALDH1A1 (0.60) | TSHRALDH1A1GLATP53CYP3A4 | |
| SCHEMBL11592157 | 0.81 | DRD4 (0.61) | DRD4ALDH1A1DRD2GLAHTR2C | |
| SCHEMBL11590992 | 0.81 | PTGDR (0.56) | TSHRDRD4ALDH1A1GLATP53 | |
| SCHEMBL13986694 | 0.80 | ALDH1A1 (0.43) | TSHRDRD4ALDH1A1DRD2GLA | |
| SCHEMBL4837178 | 0.80 | DRD4 (0.60) | TSHRDRD4ALDH1A1DRD2GLA | |
| SCHEMBL13651762 | 0.80 | DRD4 (0.60) | DRD4ALDH1A1DRD2GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1726592-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth a Corporation of the State of Delaware (US) | 2006-11-29 | — | — | EP | disclosed |
| EP-1375503-A1 | Dioxino derivatives and their use as dopanine agonists | Wyeth (US) | 2004-01-02 | — | — | EP | disclosed |
| US-5962465-A | BRAIN DISORDERS; PSYCHOLOGICAL DISORDERS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-05 | — | — | US | disclosed |
| US-5756532-A | Aminomethyl-2 3 8 9-tetrahydro-7H-1 4-dioxino 2 3-E!-indol-8-ones and derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| EP-0771800-A2 | Dioxino derivatives and their use as dopamine agonists | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-05-07 | — | — | EP | disclosed |