Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 6/20 | 0.52 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.52 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.52 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.52 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KIF11 | P52732 | 2/20 | 0.48 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17203149 | 0.89 | KDM4E (0.58) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL17205786 | 0.88 | RAB9A (0.59) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7815779 | 0.83 | GAA (0.68) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL5960232 | 0.82 | GAA (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL7356882 | 0.82 | GAA (0.49) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL15174105 | 0.79 | NR4A2 (0.69) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL9953449 | 0.77 | KIF11 (0.49) | GAAKIF11HCRTR1KDM4EALDH1A1 | |
| SCHEMBL5235955 | 0.76 | MAPT (0.43) | GABRA1GABRG2GABRB3GABRA3GABRA2 | |
| SCHEMBL19211784 | 0.75 | KIF11 (0.56) | KIF11HCRTR1KDM4EALDH1A1HPGD | |
| SCHEMBL14211006 | 0.75 | KDM4E (0.75) | KIF11HCRTR1KDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682553-A1 | THIENOPYRAZOLES | Aventis Pharmaceuticals Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005026175-A1 | THIENOPYRAZOLES | AVENTIS PHARMACEUTICALS INC. (US) | 2005-03-24 | — | — | WO | disclosed |