Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 6/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 6/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.41 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.41 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7815779 | 0.84 | GAA (0.68) | GAANR4A2GABRA1GABRA3GABRG2 | |
| SCHEMBL7356882 | 0.83 | GAA (0.49) | GAANR4A2GABRA1GABRA3GABRG2 | |
| SCHEMBL5960274 | 0.82 | GABRA1 (0.52) | GAANR4A2GABRA1GABRA3GABRG2 | |
| SCHEMBL17203149 | 0.82 | KDM4E (0.58) | GAANR4A2GABRA1GABRA3GABRG2 | |
| SCHEMBL21954408 | 0.82 | GAA (0.72) | GAAGABRA1GABRA3MAPTPKM | |
| SCHEMBL17205786 | 0.81 | RAB9A (0.59) | GAANR4A2GABRA1GABRA3GABRG2 | |
| SCHEMBL3640484 | 0.81 | CYP1A2 (0.51) | GAANR4A2GABRA1GABRA3GABRG2 | |
| SCHEMBL15174105 | 0.80 | NR4A2 (0.69) | GAANR4A2GABRA1GABRA3GABRG2 | |
| SCHEMBL2150840 | 0.79 | ALOX5 (0.40) | GAANR4A2GABRA1GABRA3GABRG2 | |
| SCHEMBL5235955 | 0.77 | MAPT (0.43) | GAANR4A2GABRA1GABRA3GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682553-A1 | THIENOPYRAZOLES | Aventis Pharmaceuticals Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005026175-A1 | THIENOPYRAZOLES | AVENTIS PHARMACEUTICALS INC. (US) | 2005-03-24 | — | — | WO | disclosed |