Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 7/20 | 0.46 |
| ▸ | MLYCD | O95822 | 2/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 6/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.36 |
| ▸ | TUBB | P07437 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960370 | 0.89 | ALOX5 (0.39) | ALOX5MLYCDPKMKDM4EALDH1A1 | |
| SCHEMBL2989755 | 0.85 | MLYCD (0.51) | ALOX5MLYCDPKMKDM4EALDH1A1 | |
| SCHEMBL1897000 | 0.80 | MLYCD (0.49) | MLYCDPKMALDH1A1GAA | |
| SCHEMBL2984808 | 0.78 | ALOX5 (0.48) | ALOX5MLYCDTUBBCA12CA9 | |
| SCHEMBL5005112 | 0.78 | ALOX5 (0.48) | ALOX5MLYCDTUBBCA12CA9 | |
| SCHEMBL2991946 | 0.77 | MLYCD (0.71) | ALOX5MLYCDTUBBCA12CA9 | |
| SCHEMBL15215299 | 0.76 | ALOX5 (0.56) | ALOX5MLYCDTUBBCA12CA9 | |
| SCHEMBL2975435 | 0.75 | ALOX5 (0.51) | ALOX5MLYCDKDM4EALDH1A1CA12 | |
| SCHEMBL15215291 | 0.74 | ALOX5 (0.54) | ALOX5MLYCD | |
| SCHEMBL2979312 | 0.74 | ALOX5 (0.41) | ALOX5MLYCDTUBBCA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636222-A1 | 7-[(1,3-THIAZOL-2-YL)THIO]-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004108720-A1 | 7- (1, 3-THIAZOL-2-YL)THIO!-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2004-12-16 | — | — | WO | disclosed |