Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.39 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.35 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960294 | 0.89 | ALOX5 (0.46) | ALOX5SCN9ASCN5AKDM4EALDH1A1 | |
| SCHEMBL2979312 | 0.86 | ALOX5 (0.41) | ALOX5TUBBMLYCD | |
| SCHEMBL2986061 | 0.80 | ALOX5 (0.41) | ALOX5KDM4ETUBBMLYCD | |
| SCHEMBL2980039 | 0.79 | MLYCD (0.56) | ALOX5KDM4ETUBBMLYCD | |
| SCHEMBL2989905 | 0.77 | ALOX5 (0.39) | ALOX5KDM4ETUBBMLYCD | |
| SCHEMBL2989755 | 0.74 | MLYCD (0.51) | ALOX5KDM4EALDH1A1GLAPOLB | |
| SCHEMBL5005164 | 0.72 | MIF (0.42) | SCN9AKDM4EALDH1A1GLAPOLB | |
| SCHEMBL2975435 | 0.71 | ALOX5 (0.51) | ALOX5KDM4EALDH1A1MLYCD | |
| SCHEMBL2985984 | 0.71 | ALOX5 (0.39) | ALOX5KDM4ETUBBMLYCD | |
| SCHEMBL2986064 | 0.69 | MLYCD (0.54) | ALOX5KDM4ETUBBMLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1636222-A1 | 7-[(1,3-THIAZOL-2-YL)THIO]-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004108720-A1 | 7- (1, 3-THIAZOL-2-YL)THIO!-COUMARIN DERIVATIVES AND THEIR USE AS LEUKOTRIENE BIOSYNTHESIS INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2004-12-16 | — | — | WO | disclosed |