Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | NR4A2 | P43354 | 7/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.47 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | F7 | P08709 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3930534 | 0.89 | HSD17B10 (0.56) | HSD17B10MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL6630345 | 0.89 | NR4A2 (0.49) | HSD17B10MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL27853728 | 0.88 | NR4A2 (0.58) | HSD17B10MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL6629905 | 0.85 | NR4A2 (0.46) | HSD17B10MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL28371975 | 0.85 | NR4A2 (0.62) | HSD17B10MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL27909264 | 0.84 | GABRA1 (0.54) | HSD17B10MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL10397437 | 0.84 | NR4A2 (0.68) | HSD17B10MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL6991795 | 0.83 | NR4A2 (0.51) | ALDH1A1HPGDNR4A2KDM4ECREBBP | |
| SCHEMBL27548934 | 0.82 | PBRM1 (0.61) | HSD17B10MEN1KMT2AALDH1A1TP53 | |
| SCHEMBL1007089 | 0.82 | NR4A2 (0.50) | MEN1KMT2AHPGDNR4A2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682553-A1 | THIENOPYRAZOLES | Aventis Pharmaceuticals Inc. (US) | 2006-07-26 | — | — | EP | disclosed |
| WO-2005026175-A1 | THIENOPYRAZOLES | AVENTIS PHARMACEUTICALS INC. (US) | 2005-03-24 | — | — | WO | disclosed |