Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 7/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.44 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.44 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.44 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.44 |
| ▸ | ASH1L | Q9NR48 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | HTR1D | P28221 | 2/20 | 0.39 |
| ▸ | HTR1B | P28222 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5960313 | 0.85 | HSD17B10 (0.50) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL6630345 | 0.85 | NR4A2 (0.49) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL27853728 | 0.84 | NR4A2 (0.58) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL28371975 | 0.82 | NR4A2 (0.62) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL1007089 | 0.81 | NR4A2 (0.50) | NR4A2MEN1KMT2AHPGDCREBBP | |
| SCHEMBL27909264 | 0.81 | GABRA1 (0.54) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL3930534 | 0.80 | HSD17B10 (0.56) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL6991795 | 0.80 | NR4A2 (0.51) | NR4A2ALDH1A1HPGDCREBBPCYP1A2 | |
| SCHEMBL6699986 | 0.79 | NR4A2 (0.72) | NR4A2GABRA1GABRG2GABRB3GABRA3 | |
| SCHEMBL15557355 | 0.79 | KDM4E (0.54) | NR4A2GABRA1GABRG2GABRB3GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483263-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070727-A1 | THIAZOLYL UREA COMPOUNDS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2003-08-28 | — | — | WO | disclosed |