Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 6/20 | 0.51 |
| ▸ | SPR | P35270 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.46 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1696922 | 0.88 | NR4A2 (0.51) | NR4A2CREBBPMAPTEGFR | |
| SCHEMBL6699986 | 0.84 | NR4A2 (0.72) | NR4A2 | |
| SCHEMBL1007089 | 0.84 | NR4A2 (0.50) | NR4A2NPSR1HPGDLMNACREBBP | |
| SCHEMBL4375343 | 0.84 | GABRG2 (0.53) | NR4A2NPSR1LMNACREBBPMAPT | |
| SCHEMBL6986880 | 0.84 | NR4A2 (0.72) | NR4A2CREBBP | |
| SCHEMBL15557355 | 0.84 | KDM4E (0.54) | NR4A2ALDH1A1HPGDTSHRCREBBP | |
| SCHEMBL5960313 | 0.83 | HSD17B10 (0.50) | NR4A2ALDH1A1NPSR1HPGDLMNA | |
| SCHEMBL6630345 | 0.83 | NR4A2 (0.49) | NR4A2ALDH1A1HPGDCREBBPKDM4E | |
| SCHEMBL6687146 | 0.82 | NR4A2 (0.48) | NR4A2ALDH1A1NPSR1LMNACREBBP | |
| SCHEMBL27853728 | 0.82 | NR4A2 (0.58) | NR4A2ALDH1A1HPGDCREBBPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108349988-A | tricyclic heterocyclic compounds as phosphoinositide 3-kinase inhibitor | 卡鲁斯治疗有限公司 | 2018-07-31 | — | — | CN | disclosed |
| CN-1245385-C | indole and indoline derivatives | HOFFMANN LA ROCHE (CH) | 2006-03-15 | — | — | CN | disclosed |
| CN-1733723-A | Indole and dihydroindole derivatives | HOFFMANN LA ROCHE (CH) | 2006-02-15 | — | — | CN | disclosed |
| CN-1476432-A | indole and indoline derivatives | - | 2004-02-18 | — | — | CN | disclosed |
| EP-1349833-A1 | INDOLE AND DIHYDROINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002044149-A1 | INDOLE AND DIHYDROINDOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2002-06-06 | — | — | WO | disclosed |