SCHEMBL5960346

SCHEMBL5960346

CC(C)C[C@H](NC(=O)OCc1ccccc1)C(O)CNCC1CCCCC1

nearest known ligand 0.50

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
CTSK P43235 13/20 0.50
REN P00797 2/20 0.50
CTSS P25774 6/20 0.49
CTSL P07711 5/20 0.49
CTSB P07858 2/20 0.47
CYP1A2 P05177 1/20 0.46
CASP1 P29466 1/20 0.45
CASP3 P42574 1/20 0.45
CASP7 P55210 1/20 0.45
CASP6 P55212 1/20 0.45
CASP8 Q14790 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3029758 0.85 CTSK (0.55) CTSKRENCTSSCTSLCTSB
SCHEMBL10570700 0.84 CTSK (0.54) CTSKRENCTSSCTSLCTSB
SCHEMBL13537000 0.83 CASP1 (0.44) CTSKCTSSCTSLCTSBCYP1A2
SCHEMBL29866155 0.83 CTSL (0.59) CTSKCTSSCTSLCTSB
SCHEMBL29865831 0.83 CTSL (0.59) CTSKCTSSCTSLCTSB
SCHEMBL5960343 0.81 CTSK (0.54) CTSKRENCTSSCTSLCTSB
SCHEMBL5960342 0.81 CTSK (0.54) CTSKRENCTSSCTSLCTSB
SCHEMBL3042938 0.80 CTSK (0.57) CTSKRENCTSSCTSLCTSB
SCHEMBL29865843 0.80 CTSK (0.57) CTSKRENCTSSCTSLCTSB
SCHEMBL3042936 0.80 CTSK (0.57) CTSKRENCTSSCTSLCTSB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1637528-A1 Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease Vertex Pharmaceuticals Incorporated (US) 2006-03-22 EP disclosed
EP-1136479-B1 Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease VERTEX PHARMA (US) 2005-12-28 EP disclosed
EP-0833826-B1 Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease VERTEX PHARMA (US) 2002-01-23 EP disclosed
EP-1136479-A1 Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease Vertex Pharmaceuticals Incorporated (US) 2001-09-26 EP disclosed
US-5990155-A VIRICIDES AGAINST THE HIV-1 AND HIV-2 VIRUSES; REVERSE TRANSCRIPTASE INHIBITORS VERTEX PHARMACEUTICALS INCORPORATED (US) 1999-11-23 US disclosed
EP-0833826-A1 OXYGENATED-HETEROCYCLE CONTAINING SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE Vertex Pharmaceuticals Incorporated (US) 1998-04-08 EP disclosed
US-5691372-A Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease VERTEX PHARMACEUTICALS INCORPORATED (US) 1997-11-25 US disclosed
WO-1996033187-A1 OXYGENATED-HETEROCYCLE CONTAINING SULFONAMIDE INHIBITORS OF ASPARTYL PROTEASE VERTEX PHARMACEUTICALS INCORPORATED (US) 1996-10-24 WO disclosed