Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | NPC1 | O15118 | 5/20 | 0.53 |
| ▸ | RAB9A | P51151 | 5/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4963929 | 0.87 | GSK3B (0.46) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL2837185 | 0.84 | RAB9A (0.73) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL10245542 | 0.71 | NPC1 (1.00) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL3612124 | 0.70 | NPC1 (0.72) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL17916200 | 0.70 | CES2 (0.54) | ALDH1A1SMN1; SMN2KDM4EPOLBLMNA | |
| SCHEMBL3825069 | 0.69 | NPC1 (0.66) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL12798159 | 0.69 | NPC1 (0.74) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL17226737 | 0.69 | RAB9A (0.77) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL4607599 | 0.69 | RAB9A (0.73) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL28372775 | 0.69 | NPC1 (0.73) | MAPTNPC1RAB9AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1709019-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2006-10-11 | — | — | EP | disclosed |
| WO-2005068444-A2 | THIAZOLE DERIVATIVES AND USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2005-07-28 | — | — | WO | disclosed |