Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 2/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29115655 | 0.82 | MTNR1A (0.54) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL7756538 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL7603630 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL7603627 | 0.80 | MTNR1A (0.49) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL3577074 | 0.77 | HDAC3 (0.53) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL3577072 | 0.77 | HDAC3 (0.53) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL3577068 | 0.77 | HDAC3 (0.53) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL9284800 | 0.76 | MTNR1A (0.45) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL5157146 | 0.75 | MTNR1A (0.51) | MTNR1AMTNR1BCYP19A1AKR1C1MEN1 | |
| SCHEMBL11712615 | 0.75 | HDAC1 (0.55) | MTNR1AMTNR1BCYP19A1AKR1C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172340-A1 | Compositions and Methods for Selectively Activating Human Sirtuins | BIOMOL INTERNATIONAL L.P. (US) | 2012-07-05 | — | — | US | disclosed |
| WO-2006004722-A2 | COMPOSITIONS AND METHODS FOR SELECTIVELY ACTIVATING HUMAN SIRTUINS | BIOMOL RESEARCH LABORATORIES, INC. (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172340-A1 | Compositions and Methods for Selectively Activating Human Sirtuins | SIRT1, SIRT7, SIRT5 | MTNR1A 1215/4885MTNR1B 2375/4885CYP19A1 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.