Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.41 |
| ▸ | ADK | P55263 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8537263 | 0.82 | TSHR (0.47) | TDP1TSHRMAPTMEN1KMT2A | |
| SCHEMBL1837259 | 0.82 | NISCH (0.50) | TSHRMAPTMEN1KMT2ANISCH | |
| SCHEMBL7427024 | 0.81 | CSNK1A1 (0.48) | MAPTNISCHALDH1A1LMNAKDM4E | |
| SCHEMBL9081929 | 0.79 | MAPT (0.51) | MAPTMEN1KMT2ANISCHALDH1A1 | |
| SCHEMBL3684600 | 0.79 | NISCH (0.50) | TSHRMAPTMEN1KMT2ANISCH | |
| SCHEMBL8539165 | 0.79 | MAPT (0.40) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL8137182 | 0.77 | NISCH (0.53) | TDP1MEN1KMT2ANISCHALDH1A1 | |
| SCHEMBL3973537 | 0.77 | MAPT (0.69) | TDP1TSHRMAPTMEN1POLB | |
| SCHEMBL5224122 | 0.75 | ALDH1A1 (0.53) | TDP1MAPTMEN1POLBKMT2A | |
| SCHEMBL13736898 | 0.75 | MAPT (0.49) | TDP1TSHRMAPTMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006014405-A2 | SULFONAMIDE-BASED COMPOUNDS AS PROTEIN TYROSINE KINASE INHIBITORS | BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM (US) | 2006-02-09 | — | — | WO | disclosed |