Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.39 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3973139 | 0.87 | PTPN1 (0.40) | NPC1RAB9APTPN1FABP4GRIA4 | |
| SCHEMBL71486 | 0.80 | PTPN1 (0.46) | NPC1RAB9APTPN1ALDH1A1HPGD | |
| SCHEMBL3978711 | 0.73 | PTPN1 (0.49) | NPC1RAB9APTPN1ALDH1A1HPGD | |
| SCHEMBL3977576 | 0.73 | PTPN1 (0.41) | NPC1RAB9APTPN1ALDH1A1HPGD | |
| SCHEMBL28130850 | 0.72 | PTPN1 (0.47) | NPC1RAB9APTPN1ALDH1A1HPGD | |
| SCHEMBL8861328 | 0.70 | FABP4 (0.41) | PTPN1FABP4ALDH1A1HPGDLMNA | |
| SCHEMBL3610930 | 0.70 | PTPN1 (0.59) | NPC1PTPN1ALDH1A1HPGDLMNA | |
| SCHEMBL3974214 | 0.69 | PTGS1 (0.48) | RAB9AALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL3361896 | 0.69 | ALDH1A1 (0.61) | ALDH1A1HPGDLMNAKDM4EGAA | |
| SCHEMBL4711778 | 0.68 | ALDH1A1 (0.46) | NPC1RAB9AALDH1A1HPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1143959-B1 | ANTIFUNGAL ACTIVITY OF DICATIONIC MOLECULES | UNIV NORTH CAROLINA (US) | 2006-11-02 | — | — | EP | disclosed |
| EP-1685836-A2 | Antifungal activity of dicationic molecules | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2006-08-02 | — | — | EP | disclosed |
| EP-0792271-B1 | FURAN DERIVATIVES FOR INHIBITING PNEUMOCYSTIS CARINII PNEUMONIA, GIARDIA LAMBLIA AND CRYPTOSPORIDIUM PARVUM | UNIV GEORGIA STATE RES FOUND (US) | 2002-02-27 | — | — | EP | disclosed |
| US-6326395-B1 | AMIDINE OR AMIDE SUBSTITUTED FURAN DERIVATIVES | DUKE UNIVERSITY | 2001-12-04 | — | — | US | disclosed |
| EP-1143959-A2 | ANTIFUNGAL ACTIVITY OF DICATIONIC MOLECULES | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2001-10-17 | — | — | EP | disclosed |
| WO-2000015212-A2 | ANTIFUNGAL ACTIVITY OF DICATIONIC MOLECULES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2000-03-23 | — | — | WO | disclosed |
| US-5602172-A | USING A 2,5-DIPHENYLFURAN COMPOUND | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1997-02-11 | — | — | US | disclosed |