Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | NPBWR1 | P48145 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | SCN4A | P35499 | 3/20 | 0.44 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | OXTR | P30559 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | AXL | P30530 | 2/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15779574 | 0.89 | OXTR (0.48) | ALDH1A1OXTRABHD16ALMNASRC | |
| SCHEMBL3244643 | 0.79 | CYP2C9 (0.52) | ALDH1A1NPBWR1NPSR1MCHR1MAPT | |
| SCHEMBL31466259 | 0.77 | NPBWR1 (0.49) | ALDH1A1NPBWR1MCHR1MAPTGAA | |
| SCHEMBL23130273 | 0.74 | CYP2C9 (0.49) | ALDH1A1NPSR1MAPTTP53LMNA | |
| SCHEMBL15299343 | 0.71 | NPC1 (0.41) | ALDH1A1NPBWR1NPSR1MAPTLMNA | |
| SCHEMBL12988815 | 0.71 | CYP2C9 (0.46) | ALDH1A1NPBWR1NPSR1MAPTTP53 | |
| SCHEMBL18725081 | 0.71 | KDM5A (0.37) | ALDH1A1NPSR1OXTRMAPTLMNA | |
| SCHEMBL19453172 | 0.71 | OXTR (0.48) | ALDH1A1NPBWR1OXTRMAPTLMNA | |
| SCHEMBL31466271 | 0.70 | OXTR (0.44) | NPBWR1MCHR1OXTRMAPTSRC | |
| SCHEMBL255499 | 0.70 | POLB (0.57) | ALDH1A1NPSR1MAPTLMNACYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1292577-B1 | ARYL SUBSTITUTED PYRAZOLES, TRIAZOLES AND TETRAZOLES AS SODIUM CHANNEL BLOCKER | EURO CELTIQUE SA (LU) | 2012-10-24 | — | — | EP | disclosed |
| CN-1321112-C | Aryl substituted pyrazoles, triazoles and tetrazoles as sodium channel blocker | EURO CELTIQUE SA (LU) | 2007-06-13 | — | — | CN | disclosed |
| US-7078426-B2 | Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof | EURO-CELTIQUE S.A. (LU) | 2006-07-18 | — | — | US | disclosed |
| US-6919363-B2 | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof | EURO-CELTIQUE S.A. (LU) | 2005-07-19 | — | — | US | disclosed |
| US-20040002523-A1 | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof | EURO-CELTIQUE S.A. | 2004-01-01 | — | — | US | disclosed |
| CN-1422257-A | Aryl substituted pyrazoles, triazoles and tetrazoles as sodium channel blocker | EURO CELTIQUE SA (LU) | 2003-06-04 | — | — | CN | disclosed |
| EP-1292577-A2 | ARYL SUBSTITUTED PYRAZOLES, TRIAZOLES AND TETRAZOLES AS SODIUM CHANNEL BLOCKER | Euro-Celtique S.A. (LU) | 2003-03-19 | — | — | EP | disclosed |
| US-20020006947-A1 | Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof | PURDUE PHARMA L.P. | 2002-01-17 | — | — | US | disclosed |
| WO-2001072714-A2 | ARYL SUBSTITUTED PYRAZOLES, TRIAZOLES AND TETRAZOLES AS SODIUM CHANNEL BLOCKER | EURO-CELTIQUE S.A. (LU) | 2001-10-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040002523-A1 | Aryl substituted pyrazoles, triazoles and tetrazoles, and the use thereof | CACNA1I, GRIK5, SOD1 | ALDH1A1 413/4885NPBWR1 2533/4885NPSR1 632/4885 |
| US-20020006947-A1 | Aryl substituted pyrazoles, triazoles, and tetrazoles, and the use thereof | GRIK5, CACNA1I, SOD1 | ALDH1A1 431/4885NPBWR1 2672/4885NPSR1 729/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.