Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 2/20 | 0.41 |
| ▸ | FNTB | P49356 | 2/20 | 0.41 |
| ▸ | PGGT1B | P53609 | 2/20 | 0.41 |
| ▸ | F13A1 | P00488 | 4/20 | 0.41 |
| ▸ | TGM2 | P21980 | 4/20 | 0.41 |
| ▸ | TGM1 | P22735 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5965504 | 0.88 | HRH1 (0.43) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL5965768 | 0.84 | HRH1 (0.40) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL5965533 | 0.84 | CYP19A1 (0.39) | HRH1MMP9THRB | |
| SCHEMBL5965664 | 0.83 | HRH1 (0.38) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL5965612 | 0.82 | HRH1 (0.45) | L3MBTL1HTR1ADRD4HTR2AHRH1 | |
| SCHEMBL5965534 | 0.82 | GPR119 (0.44) | HRH1 | |
| SCHEMBL5965861 | 0.82 | L3MBTL1 (0.48) | L3MBTL1HTR1ADRD4HTR2AHRH1 | |
| SCHEMBL5965789 | 0.80 | EPHX2 (0.42) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL5965740 | 0.80 | HRH1 (0.44) | HTR1ADRD4HTR2AHRH1OPRM1 | |
| SCHEMBL5965757 | 0.80 | HRH2 (0.36) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7012074-B2 | 3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2006-03-14 | — | — | US | disclosed |
| US-20040023971-A1 | 3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias | ASTRAZENECA AB (SE) | 2004-02-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040023971-A1 | 3,8-Diazabicyclo[3.2.1]octanes and their use in the treatment of cardiac arrhythmias | KCNH1, KCNH2, RYR2 | L3MBTL1 922/4885HTR1A 1324/4885DRD4 623/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.