Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 3/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.48 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.47 |
| ▸ | BACE1 | P56817 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL34468451 | 0.96 | MDM4 (0.54) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL20211701 | 0.94 | MDM4 (0.54) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL15630864 | 0.94 | MDM4 (0.54) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL15630865 | 0.94 | MDM4 (0.54) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL22108945 | 0.89 | MDM4 (0.51) | MDM4TP53MDM2CASP3BACE1 | |
| SCHEMBL9449850 | 0.89 | MDM4 (0.51) | MDM4TP53MDM2CASP3KMT2A | |
| SCHEMBL16059782 | 0.88 | MDM2 (0.55) | MDM4TP53MDM2CASP3 | |
| SCHEMBL30660220 | 0.88 | MDM4 (0.50) | MDM4TP53MDM2CASP3BACE1 | |
| SCHEMBL13163967 | 0.87 | CASP3 (0.57) | MDM4TP53MDM2CASP3KMT2A | |
| SCHEMBL7423417 | 0.87 | CASP3 (0.57) | MDM4TP53MDM2CASP3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144858-B2 | Antibacterial compounds and methods for treating Gram positive bacterial infections | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2006-12-05 | — | — | US | disclosed |
| WO-2003101393-A2 | ANTIBACTERIAL COMPOUNDS AND METHODS FOR TREATING GRAM POSITIVE BACTERIAL INFECTIONS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2003-12-11 | — | — | WO | disclosed |