Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.54 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 4/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15630865 | 1.00 | MDM4 (0.54) | MDM4TP53MDM2CASP3IDO1 | |
| SCHEMBL20211701 | 1.00 | MDM4 (0.54) | MDM4TP53MDM2CASP3IDO1 | |
| SCHEMBL34468451 | 0.98 | MDM4 (0.54) | MDM4TP53MDM2CASP3IDO1 | |
| SCHEMBL5969952 | 0.94 | MDM4 (0.54) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL16059782 | 0.90 | MDM2 (0.55) | MDM4TP53MDM2CASP3 | |
| SCHEMBL28306682 | 0.89 | MDM4 (0.52) | MDM4TP53MDM2CASP3IDO1 | |
| SCHEMBL30945050 | 0.89 | MDM4 (0.60) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL29091196 | 0.89 | MDM4 (0.60) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL8897778 | 0.89 | MDM4 (0.60) | MDM4TP53MDM2CASP3SLC17A5 | |
| SCHEMBL16059779 | 0.89 | MDM2 (0.58) | MDM4TP53MDM2CASP3IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180163257-A1 | BIOPROBES AND METHODS OF USE THEREOF | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2018-06-14 | — | — | US | disclosed |
| US-9816129-B2 | Bioprobes and methods of use thereof | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2017-11-14 | — | — | US | disclosed |
| US-9335289-B2 | Bioprobes and methods of use thereof | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2016-05-10 | — | — | US | disclosed |
| US-20140087375-A1 | BIOPROBES AND METHODS OF USE THEREOF | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2014-03-27 | — | — | US | disclosed |