Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT5 | Q9NXA8 | 4/20 | 0.47 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | CPA1 | P15085 | 1/20 | 0.37 |
| ▸ | CPA2 | P48052 | 1/20 | 0.37 |
| ▸ | CPA4 | Q9UI42 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 4/20 | 0.35 |
| ▸ | SIRT1 | Q96EB6 | 4/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5970307 | 0.93 | CPA1 (0.42) | SIRT5CPA1CPA2CPA4HDAC1 | |
| SCHEMBL5970130 | 0.88 | HPGDS (0.49) | SIRT5HPGDSCPA1CPA2CPA4 | |
| SCHEMBL5970058 | 0.88 | HPGDS (0.49) | SIRT5HPGDSCPA1CPA2CPA4 | |
| SCHEMBL5970300 | 0.86 | SIRT5 (0.52) | SIRT5HPGDSCPA1CPA2CPA4 | |
| SCHEMBL5970942 | 0.86 | SIRT5 (0.52) | SIRT5HPGDSCPA1CPA2CPA4 | |
| SCHEMBL5970135 | 0.85 | SIRT5 (0.46) | SIRT5HPGDSCPA1CPA2CPA4 | |
| SCHEMBL5970592 | 0.84 | SIRT5 (0.54) | SIRT5HPGDSCPA1CPA2CPA4 | |
| SCHEMBL5970251 | 0.83 | SIRT5 (0.48) | SIRT5HPGDSCPA1CPA2CPA4 | |
| SCHEMBL5970241 | 0.83 | SIRT5 (0.48) | SIRT5HPGDSCPA1CPA2CPA4 | |
| SCHEMBL5970299 | 0.81 | FNTA (0.46) | SIRT5CPA1CPA2CPA4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1080070-B1 | ANTIANGIOGENIC DRUG TO TREAT CANCER, ARTHRITIS AND RETINOPATHY | ABBOTT LAB (US) | 2006-11-22 | — | — | EP | claimed |