⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5752779 | 0.87 | — | — | |
| SCHEMBL30932481 | 0.71 | — | — | |
| SCHEMBL7661380 | 0.62 | — | — | |
| SCHEMBL78004 | 0.62 | — | — | |
| SCHEMBL1307873 | 0.62 | — | — | |
| SCHEMBL348778 | 0.62 | — | — | |
| SCHEMBL3218192 | 0.61 | — | — | |
| SCHEMBL3930783 | 0.61 | NAAA (0.48) | — | |
| SCHEMBL12347748 | 0.60 | POLB (0.35) | — | |
| SCHEMBL21936377 | 0.60 | POLB (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1928456-B1 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS INC (US) | 2015-04-22 | — | — | EP | disclosed |
| US-8114870-B2 | Method of treating disease states using substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. (US) | 2012-02-14 | — | — | US | disclosed |
| US-20090264422-A1 | METHOD OF TREATING DISEASE STATES USING SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. | 2009-10-22 | — | — | US | disclosed |
| US-7563787-B2 | Substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. (US) | 2009-07-21 | — | — | US | disclosed |
| EP-1928456-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS | Miikana Therapeutics, Inc. (US) | 2008-06-11 | — | — | EP | disclosed |
| US-20070142368-A1 | Substituted pyrazole compounds | MIIKANA THERAPEUTICS, INC. | 2007-06-21 | — | — | US | disclosed |
| WO-2007041358-A2 | SUBSTITUTED PYRAZOLE COMPOUNDS | MIIKANA THERAPEUTICS, INC. (US) | 2007-04-12 | — | — | WO | disclosed |