Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TACR1 | P25103 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5130053 | 0.83 | PNMT (0.58) | PNMTTSHRSMN1; SMN2TACR1SIGMAR1 | |
| SCHEMBL5234992 | 0.83 | PNMT (0.58) | PNMTTSHRSMN1; SMN2TACR1HRH3 | |
| SCHEMBL6005581 | 0.83 | PNMT (0.58) | PNMTTSHRSMN1; SMN2TACR1SIGMAR1 | |
| SCHEMBL6003855 | 0.83 | PNMT (0.58) | PNMTTSHRSMN1; SMN2TACR1SIGMAR1 | |
| SCHEMBL12220066 | 0.82 | PNMT (0.57) | PNMTTSHRSMN1; SMN2CYP3A4TACR1 | |
| SCHEMBL14374193 | 0.80 | TACR1 (0.47) | PNMTTSHRSMN1; SMN2CYP3A4TACR1 | |
| SCHEMBL8221816 | 0.79 | TSHR (0.55) | PNMTTSHRSMN1; SMN2TACR1SLC6A3 | |
| SCHEMBL6573908 | 0.79 | TSHR (0.55) | PNMTTSHRSMN1; SMN2TACR1SLC6A3 | |
| SCHEMBL2428822 | 0.77 | SMN1; SMN2 (0.52) | PNMTTSHRSMN1; SMN2TACR1SLC6A2 | |
| SCHEMBL19369775 | 0.76 | TACR1 (0.44) | PNMTTSHRSMN1; SMN2CYP3A4TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1429811-A4 | THEURAPEUTIC TROPANE COMPOUNDS | HARVARD COLLEGE (US) | 2006-05-17 | — | — | EP | claimed |
| EP-1429811-A1 | THEURAPEUTIC TROPANE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2004-06-23 | — | — | EP | claimed |
| WO-2003015830-A1 | THEURAPEUTIC TROPANE COMPOUNDS | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2003-02-27 | — | — | WO | claimed |