Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 3/20 | 0.40 |
| ▸ | PDE4A | P27815 | 2/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ciaftalan SCHEMBL8965441 | 0.91 | PDE5A (0.37) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Ciaftalan SCHEMBL11520284 | 0.90 | MEN1 (0.39) | KDM4ELMNAHTTSMN1; SMN2TSHR | |
| Ciaftalan SCHEMBL11414517 | 0.86 | PDE5A (0.39) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Ciaftalan SCHEMBL9075585 | 0.84 | ELANE (0.36) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Ciaftalan SCHEMBL7950273 | 0.84 | HPGD (0.39) | PDE5AALDH1A1LMNATSHRHSD17B10 | |
| SCHEMBL5707000 | 0.84 | PDE5A (0.45) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28035087 | 0.84 | PDE5A (0.46) | PDE5APDE4APDE4BPDE4CPDE4D | |
| SCHEMBL28034499 | 0.84 | PDE5A (0.46) | PDE5APDE4APDE4BPDE4CPDE4D | |
| Ciaftalan SCHEMBL28514833 | 0.83 | TLR8 (0.44) | ALDH1A1TSHRELANETLR8 | |
| Ciaftalan SCHEMBL29211555 | 0.83 | TLR8 (0.44) | ALDH1A1TSHRELANETLR8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7083984-B2 | Hybrid phthalocyanine derivatives and their uses | BIOSITE, INC. (US) | 2006-08-01 | — | — | US | disclosed |
| US-6964844-B1 | Hybrid phthalocyanine derivatives and their uses | BIOSITE, INC. (US) | 2005-11-15 | — | — | US | disclosed |