Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 3/20 | 0.33 |
| ▸ | ACHE | P22303 | 2/20 | 0.33 |
| ▸ | GALR2 | O43603 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5974463 | 0.86 | HTT (0.42) | HTTMAPTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL14836661 | 0.75 | LMNA (0.41) | HTTMAPTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL5973243 | 0.73 | TLR7 (0.46) | HTTMAPTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL5418906 | 0.73 | MEN1 (0.49) | HTTMAPTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL4846686 | 0.69 | POLB (0.32) | POLB | |
| SCHEMBL11675190 | 0.69 | PGK1 (0.48) | MAPTSMN1; SMN2TDP1LMNANPC1 | |
| SCHEMBL2178028 | 0.68 | ALDH1A1 (0.35) | HTTMAPTSMN1; SMN2RAB9AKMT2A | |
| SCHEMBL11676864 | 0.67 | DPP4 (0.40) | HTTMAPTKMT2AMEN1TDP1 | |
| SCHEMBL5973745 | 0.67 | GRIN2D (0.38) | MAPTSMN1; SMN2KMT2AMEN1LMNA | |
| SCHEMBL7217092 | 0.66 | ABCG2 (0.43) | HTTMAPTSMN1; SMN2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE39112-E1 | Purine derivatives and adenosine A2 receptor antagonists serving as preventives/remedies for diabetes | EISAI CO., LTD. (JP) | 2006-05-30 | — | — | US | disclosed |
| US-6579868-B1 | Reacting a 2,6-dihalo-substituted purine compound with ammonia or an amine | EISAI CO., LTD. (JP) | 2003-06-17 | — | — | US | disclosed |
| EP-1054012-B1 | PURINE DERIVATIVES AND ADENOSINE A2 RECEPTOR ANTAGONISTS SERVING AS PREVENTIVES/REMEDIES FOR DIABETES | EISAI CO LTD (JP) | 2003-06-11 | — | — | EP | disclosed |
| EP-1300147-A1 | Purine compounds and adenosine A2 receptor antagonist as preventive or therapeutic agent for diabetes mellitus | Eisai Co. Ltd (JP) | 2003-04-09 | — | — | EP | disclosed |
| EP-1054012-A1 | PURINE DERIVATIVES AND ADENOSINE A2 RECEPTOR ANTAGONISTS SERVING AS PREVENTIVES/REMEDIES FOR DIABETES | Eisai Co., Ltd. (JP) | 2000-11-22 | — | — | EP | disclosed |