Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR17 | Q13304 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL599521 | 0.79 | DAO (0.33) | KDM4EGAASMN1; SMN2 | |
| SCHEMBL11325534 | 0.73 | RXFP1 (0.49) | MAPTKDM4EALDH1A1GAAMEN1 | |
| SCHEMBL649606 | 0.72 | AKR1C3 (0.41) | ALDH1A1 | |
| SCHEMBL18029143 | 0.72 | GPR17 (0.46) | GPR17MAPTKDM4EALDH1A1GAA | |
| SCHEMBL598456 | 0.71 | KDM4E (0.59) | GPR17FEN1MAPTKDM4EALDH1A1 | |
| SCHEMBL260657 | 0.71 | CYP1A2 (0.40) | MAPTSMN1; SMN2MEN1KMT2ATDP1 | |
| SCHEMBL11219094 | 0.68 | PLA2G2A (0.35) | MAPTALDH1A1GAAPLA2G2AMCL1 | |
| SCHEMBL2542691 | 0.68 | GABRA1 (0.44) | MAPTKDM4EALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8298676 | 0.68 | KDM4E (0.47) | GPR17MAPTKDM4EALDH1A1GAA | |
| SCHEMBL22609023 | 0.67 | AHR (0.52) | GPR17FEN1MAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8115014-B2 | Ethynylindole compounds | ONO Pharmaceuticals, Co., Ltd. (JP) | 2012-02-14 | — | — | US | disclosed |