Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.65 |
| ▸ | PIM1 | P11309 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.54 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4600722 | 0.81 | AURKA (1.00) | AURKAPIM1CDK2GSK3BHSD17B10 | |
| SCHEMBL23069040 | 0.76 | AURKA (0.88) | AURKAPIM1CDK2GSK3BHSD17B10 | |
| SCHEMBL909845 | 0.74 | HSD17B10 (1.00) | HSD17B10GABRA5GABRB2SMN1; SMN2MAPT | |
| SCHEMBL27861124 | 0.73 | SMN1; SMN2 (0.73) | AURKAPIM1CDK2GSK3BSMN1; SMN2 | |
| SCHEMBL9864403 | 0.72 | HSD17B10 (0.96) | HSD17B10GABRA5GABRB2SMN1; SMN2MAPT | |
| Hydrochloric Acid SCHEMBL9694699 | 0.72 | GABRA5 (0.96) | HSD17B10GABRA5GABRB2SMN1; SMN2MAPT | |
| SCHEMBL5979453 | 0.72 | LMNA (0.41) | AURKAPIM1CDK2GSK3BHSD17B10 | |
| SCHEMBL24101691 | 0.72 | MAPT (0.70) | AURKAPIM1CDK2GSK3BSMN1; SMN2 | |
| SCHEMBL28796060 | 0.71 | NPC1 (0.71) | AURKAPIM1CDK2GSK3BSMN1; SMN2 | |
| Methyl Alcohol SCHEMBL10946415 | 0.71 | HSD17B10 (0.93) | HSD17B10GABRA5GABRB2SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1353676-A4 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS | ALTEON INC (US) | 2006-05-31 | — | — | EP | disclosed |
| EP-1353676-A1 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS | Alteon, Inc. (US) | 2003-10-22 | — | — | EP | disclosed |
| WO-2002053161-A1 | METHOD FOR TREATING FIBROTIC DISEASES OR OTHER INDICATIONS | ALTEON, INC. (US) | 2002-07-11 | — | — | WO | disclosed |