Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.47 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.41 |
| ▸ | SNCA | P37840 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL14778247 | 0.98 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Iodide SCHEMBL16935789 | 0.98 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL28894091 | 0.96 | HIF1A (0.58) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL9810148 | 0.96 | HIF1A (0.58) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| SCHEMBL35210196 | 0.96 | HIF1A (0.58) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL16197577 | 0.94 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL35210203 | 0.94 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL2743878 | 0.94 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL18641785 | 0.94 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL28887485 | 0.94 | HIF1A (0.56) | HIF1AALDH1A1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609643-B2 | 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-12-17 | — | — | US | disclosed |
| US-8399439-B2 | 2-methylene-19,26-dinor-(20S,22E,25R)-vitamin D analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2013-03-19 | — | — | US | disclosed |
| US-20120283228-A1 | 2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-11-08 | — | — | US | disclosed |
| US-8193170-B2 | 2-methylene-19,26-dinor-(20R,22E,25R)-vitamin D analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-06-05 | — | — | US | disclosed |
| US-8114859-B2 | anticarcinogenic agent; arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte; inhibiting adipocyte differentiation and stearoyl CoA desaturase (SCD-1) gene transcription; skin disorder, psoriasis, obesity, antiinflammatory agent | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2012-02-14 | — | — | US | disclosed |
| US-7947666-B2 | 2-methylene-(20S,25S)-19,26-dinor-vitamin D analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2011-05-24 | — | — | US | disclosed |
| US-7803789-B2 | Vitamin D analog—RAK, methods and uses thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-09-28 | — | — | US | disclosed |
| US-7741314-B2 | 2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2010-06-22 | — | — | US | disclosed |
| US-20100009946-A1 | 2-Methylene-19,26-Dinor-(20R,22E,25R)-Vitamin D Analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-01-14 | — | — | US | disclosed |
| US-20100009947-A1 | 2-Methylene-19,26-Dinor-(20S,22E,25R)-Vitamin D Analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2010-01-14 | — | — | US | disclosed |
| EP-1984329-B1 | VITAMIN D ANALOG - RAK, METHODS AND USES THEREOF | WISCONSIN ALUMNI RES FOUND (US) | 2009-12-09 | — | — | EP | disclosed |
| US-20090170821-A1 | 2-Methylene-(20S,25S)-19,26-Dinor-Vitamin D Analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2009-07-02 | — | — | US | disclosed |
| US-20090170820-A1 | 2-Methylene-(20S,25R)-19,26-Dinor-Vitamin D Analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2009-07-02 | — | — | US | disclosed |
| EP-2069297-A1 | 2-METHYLENE-(20R,25S)-19,27-DINOR-(22E)-VITAMIN D ANALOGS | Wisconsin Alumni Research Foundation (US) | 2009-06-17 | — | — | EP | disclosed |
| US-7528122-B2 | Vitamin D analog—NEL, methods and uses thereof | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2009-05-05 | — | — | US | disclosed |
| US-20080081799-A1 | 2-Methylene-(20S,25S)-19,27-Dinor-(22E)-Vitamin D Analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-04-03 | — | — | US | disclosed |
| WO-2008039754-A1 | 2-METHYLENE-(20R,25S)-19,27-DINOR-(22E)-VITAMIN D ANALOGS | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2008-04-03 | — | — | WO | disclosed |
| US-20080081800-A1 | 2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs | WISCONSIN ALUMNI RESEARCH FOUNDATION | 2008-04-03 | — | — | US | disclosed |
| US-20070191316-A1 | VITAMIN D ANALOG - NEL, METHODS AND USES THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-08-16 | — | — | US | disclosed |
| US-20070191317-A1 | VITAMIN D ANALOG - RAK, METHODS AND USES THEREOF | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 2007-08-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070191317-A1 | VITAMIN D ANALOG - RAK, METHODS AND USES THEREOF | VDR, CYP24A1, CYP2R1 | HIF1A 1579/4885ALDH1A1 675/4885CYP1A2 274/4885 |
| US-20090170820-A1 | 2-Methylene-(20S,25R)-19,26-Dinor-Vitamin D Analogs | CYP24A1, VDR, CYP27B1 | HIF1A 2003/4885ALDH1A1 1471/4885CYP1A2 2751/4885 |
| US-20100009946-A1 | 2-Methylene-19,26-Dinor-(20R,22E,25R)-Vitamin D Analogs | VDR, CYP24A1, CYP27B1 | HIF1A 1795/4885ALDH1A1 2854/4885CYP1A2 3564/4885 |
| US-20090170821-A1 | 2-Methylene-(20S,25S)-19,26-Dinor-Vitamin D Analogs | CYP24A1, VDR, CYP27B1 | HIF1A 1971/4885ALDH1A1 1410/4885CYP1A2 2617/4885 |
| US-20080081799-A1 | 2-Methylene-(20S,25S)-19,27-Dinor-(22E)-Vitamin D Analogs | CYP24A1, CYP27B1, VDR | HIF1A 2225/4885ALDH1A1 1527/4885CYP1A2 2547/4885 |
| US-20080081800-A1 | 2-Methylene-(20R,25S)-19,27-Dinor-(22E)-Vitamin D Analogs | CYP24A1, VDR, CYP2R1 | HIF1A 2281/4885ALDH1A1 1581/4885CYP1A2 2537/4885 |
| US-20070191316-A1 | VITAMIN D ANALOG - NEL, METHODS AND USES THEREOF | VDR, CYP24A1, CYP2R1 | HIF1A 2230/4885ALDH1A1 752/4885CYP1A2 446/4885 |
| US-20120283228-A1 | 2alpha-Methyl and 2beta-Methyl Analogs of 19,26-Dinor-1alpha,25-Dihydroxyvitamin D3 and Their Uses | CYP24A1, VDR, CYP27B1 | HIF1A 1084/4885ALDH1A1 2409/4885CYP1A2 2545/4885 |
| US-20100009947-A1 | 2-Methylene-19,26-Dinor-(20S,22E,25R)-Vitamin D Analogs | CYP24A1, VDR, CYP27B1 | HIF1A 2133/4885ALDH1A1 2856/4885CYP1A2 3313/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.