Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adenosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA1 known ✓ | P30542 | 4/20 | 0.65 |
| ▸ | ADORA3 known ✓ | P0DMS8 | 4/20 | 0.65 |
| ▸ | ADORA2A known ✓ | P29274 | 2/20 | 0.65 |
| ▸ | ADORA2B known ✓ | P29275 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | DPP4 | P27487 | 1/20 | 0.65 |
| ▸ | MEN1 | O00255 | 1/20 | 0.65 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.65 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.65 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.65 |
| ▸ | GAPDH | P04406 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | STAT6 | P42226 | 1/20 | 0.65 |
| ▸ | PI4KA | P42356 | 1/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.65 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.65 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.65 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.65 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.65 |
| ▸ | SLC28A3 | Q9HAS3 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adenosine SCHEMBL560740 | 0.97 | ADORA3 (0.70) | ADORA1ADORA3SMN1; SMN2ADORA2ADPP4 | |
| Adenosine SCHEMBL28391361 | 0.97 | ADORA3 (0.70) | ADORA1ADORA3SMN1; SMN2ADORA2ADPP4 | |
| Adenosine SCHEMBL6803120 | 0.93 | ADORA1 (0.65) | ADORA1ADORA3SMN1; SMN2ADORA2ADPP4 | |
| Niacinamide SCHEMBL28249016 | 0.90 | ADH1A (0.66) | SMN1; SMN2ADH1AIMPDH2NADKIMPDH1 | |
| Adenosine Phosphate SCHEMBL160972 | 0.90 | P2RY1 (0.75) | ADORA1SMN1; SMN2ADH1AIMPDH2NADK | |
| Adenosine Phosphate SCHEMBL27419541 | 0.90 | P2RY1 (0.75) | ADORA1SMN1; SMN2ADH1AIMPDH2NADK | |
| Adenosine SCHEMBL11028276 | 0.89 | ADORA3 (0.68) | ADORA1ADORA3SMN1; SMN2ADORA2ADPP4 | |
| Adenosine Diphosphate SCHEMBL570243 | 0.87 | ADH1A (0.74) | SMN1; SMN2ADH1AIMPDH2NADKIMPDH1 | |
| Adenosine SCHEMBL3296155 | 0.87 | ADORA3 (0.83) | ADORA1ADORA3SMN1; SMN2ADORA2ADPP4 | |
| Adenosine Triphosphate SCHEMBL811698 | 0.86 | ADH1A (0.75) | SMN1; SMN2ADH1AIMPDH2NADKIMPDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040156873-A1 | Topically Bioavailable Acne and Rosacea Treatment Compositions | GUPTA SHYAM K (US) | 2004-08-12 | — | — | US | claimed |
| US-20040081672-A1 | Niacinamide, niacin, and niacin esters based delivery systems for treating topical disorders of skin and skin aging | GUPTA SHYAM K (US) | 2004-04-29 | — | — | US | claimed |
| US-10173942-B2 | Non-corrosive nitrification inhibitor polar solvent formulation | DOW AGROSCIENCES, LLC (US) | 2019-01-08 | — | — | US | disclosed |
| US-10173943-B2 | Non-corrosive nitrification inhibitor polar solvent formulation | DOW AGROSCIENCES, LLC (US) | 2019-01-08 | — | — | US | disclosed |
| WO-2017069828-A1 | NON-CORROSIVE NITRIFICATION INHIBITOR POLAR SOLVENT FORMULATION | DOW AGROSCIENCES, LLC (US) | 2017-04-27 | — | — | WO | disclosed |
| WO-2017069827-A1 | NON-CORROSIVE NITRIFICATION INHIBITOR POLAR SOLVENT FORMULATION | DOW AGROSCIENCES, LLC (US) | 2017-04-27 | — | — | WO | disclosed |
| US-20160332930-A1 | NON-CORROSIVE NITRIFICATION INHIBITOR POLAR SOLVENT FORMULATION | SPECIALTY OPERATIONS FRANCE (FR) | 2016-11-17 | — | — | US | disclosed |
| US-20160332931-A1 | NON-CORROSIVE NITRIFICATION INHIBITOR POLAR SOLVENT FORMULATION | SPECIALTY OPERATIONS FRANCE (FR) | 2016-11-17 | — | — | US | disclosed |
| WO-2006023710-A2 | COSMETIC OR PHARMACEUTICAL COMPOSITION FOR SKIN CARE | INFINITY2 HEALTH SCIENCES, INC. (US) | 2006-03-02 | — | — | WO | disclosed |
| US-20060039887-A1 | Cosmetic or pharmaceutical composition for skin care | INFINITY2 HEALTH SCIENCES, INC. | 2006-02-23 | — | — | US | disclosed |
| US-20040228884-A1 | Ion-pair delivery system for cosmetic and pharmaceutical compositions | GUPTA SHYAM K (US) | 2004-11-18 | — | — | US | disclosed |