Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28710805 | 0.98 | SLC6A3 (0.42) | SLC6A3SLC6A2MDM2ADRA1ASLC6A4 | |
| SCHEMBL29940424 | 0.85 | SLC6A3 (0.53) | SLC6A3SLC6A2ADRA1ASLC6A4HSD11B1 | |
| SCHEMBL1067433 | 0.85 | SLC6A3 (0.53) | SLC6A3SLC6A2ADRA1ASLC6A4HSD11B1 | |
| SCHEMBL25918375 | 0.79 | KDM1A (0.43) | ALDH1A1KMT2AHTR2AHTR2CHTR2B | |
| SCHEMBL2858394 | 0.79 | HCRTR2 (0.40) | HTR2AHTR2CHTR2BDRD4GRM2 | |
| SCHEMBL28710812 | 0.79 | HTR2C (0.57) | SLC6A3SLC6A4HTTKMT2AHTR2A | |
| SCHEMBL8932658 | 0.79 | HCRTR2 (0.40) | HTR2AHTR2CHTR2BDRD4GRM2 | |
| SCHEMBL8972206 | 0.78 | HTR3A (0.44) | SLC6A3SLC6A2HTTALDH1A1KMT2A | |
| SCHEMBL5271028 | 0.78 | HTR3A (0.44) | SLC6A3SLC6A2HTTALDH1A1KMT2A | |
| SCHEMBL10386998 | 0.77 | SLC18A3 (0.48) | ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1667959-A1 | BIPHENYLOXY-ACIDS | Wyeth (US) | 2006-06-14 | — | — | EP | disclosed |
| WO-2005030702-A1 | BIPHENYLOXY-ACIDS | WYETH (US) | 2005-04-07 | — | — | WO | disclosed |