SCHEMBL8972206

SCHEMBL8972206

O=C[C@H]1CC[C@H](c2ccc(Cl)cc2)CC1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR3A P46098 1/20 0.44
SLC2A1 P11166 1/20 0.44
SLC18A3 Q16572 1/20 0.44
DRD2 P14416 1/20 0.43
MAPT P10636 2/20 0.43
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
TP53 P04637 2/20 0.43
USP2 O75604 1/20 0.43
LMNA P02545 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2C9 P11712 1/20 0.43
HPGD P15428 1/20 0.43
TSHR P16473 1/20 0.43
HIF1A Q16665 1/20 0.43
SRD5A1 P18405 2/20 0.41
IDO1 P14902 1/20 0.41
MAP1LC3B Q9GZQ8 1/20 0.40
HSD17B10 Q99714 2/20 0.40
ALDH1A1 P00352 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5271028 1.00 HTR3A (0.44) HTR3ASLC2A1SLC18A3DRD2MAPT
Hydrochloric Acid SCHEMBL28701325 0.98 HTR3A (0.43) HTR3ASLC2A1SLC18A3DRD2MAPT
SCHEMBL9182846 0.94 SLC2A1 (0.41) HTR3ASLC2A1SLC18A3DRD2MAPT
Sulfurous Acid SCHEMBL9940685 0.91 SLC18A3 (0.42) HTR3ASLC2A1SLC18A3DRD2MAPT
Sulfurous Acid SCHEMBL9940687 0.91 SLC18A3 (0.42) HTR3ASLC2A1SLC18A3DRD2MAPT
SCHEMBL9311909 0.90 IDO1 (0.45) HTR3ASLC2A1SLC18A3DRD2MAPT
SCHEMBL8517580 0.90 IDO1 (0.45) HTR3ASLC2A1SLC18A3DRD2MAPT
SCHEMBL6853901 0.89 HDAC2 (0.43) CYP2C9POLBHDAC2
SCHEMBL10693588 0.89 HTR3A (0.42) HTR3ASLC2A1SLC18A3DRD2MAPT
SCHEMBL6451314 0.83 HTR3A (0.38) HTR3ASLC2A1SLC18A3DRD2MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115490582-B Preparation method of fluorine-containing biphenyl alkene negative monomer liquid crystal compound 烟台德润液晶材料有限公司 2023-10-10 CN claimed
CN-115490582-A Preparation method of fluorine-containing biphenyl alkene negative monomer liquid crystal compound 烟台德润液晶材料有限公司 2022-12-20 CN claimed
US-12606533-B2 3-phenylpropylamine derivative DAIICHI SANKYO COMPANY, LIMITED (JP) 2026-04-21 US disclosed
US-20250353824-A1 3-PHENYLPROPYLAMINE DERIVATIVE DAIICHI SANKYO COMPANY, LIMITED (JP) 2025-11-20 US disclosed
CN-115490582-B Preparation method of fluorine-containing biphenyl alkene negative monomer liquid crystal compound 烟台德润液晶材料有限公司 2023-10-10 CN disclosed
CN-115490582-B Preparation method of fluorine-containing biphenyl alkene negative monomer liquid crystal compound 烟台德润液晶材料有限公司 2023-10-10 CN disclosed
CN-115490582-A Preparation method of fluorine-containing biphenyl alkene negative monomer liquid crystal compound 烟台德润液晶材料有限公司 2022-12-20 CN disclosed
CN-115490582-A Preparation method of fluorine-containing biphenyl alkene negative monomer liquid crystal compound 烟台德润液晶材料有限公司 2022-12-20 CN disclosed
EP-3350164-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF Metacrine, Inc. (US) 2018-07-25 EP disclosed
WO-2017049176-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF METACRINE, INC. (US) 2017-03-23 WO disclosed
WO-2017049176-A1 FARNESOID X RECEPTOR AGONISTS AND USES THEREOF METACRINE, INC. (US) 2017-03-23 WO disclosed
US-20130267717-A1 PROCESS FOR THE PREPARATION OF ATOVAQUONE GLAXO GROUP LIMITED (GB) 2013-10-10 US disclosed
WO-2012080243-A2 NOVEL PROCESS GLAXO GROUP LIMITED (GB) 2012-06-21 WO disclosed
WO-2012080243-A2 NOVEL PROCESS GLAXO GROUP LIMITED (GB) 2012-06-21 WO disclosed
EP-0433836-B1 Halophenyl substituted dioxanes HOFFMANN LA ROCHE (CH) 1996-03-27 EP disclosed
US-5399689-A Chlorophenylalkoxyalkyl compounds HOFFMANN-LA ROCHE INC. (US) 1995-03-21 US disclosed
EP-0475254-B1 Chlorophenyl-alkoxyalkyl-compounds HOFFMANN LA ROCHE (CH) 1994-12-28 EP disclosed
US-5322638-A Halophenyl substituted dioxanes HOFFMANN-LA ROCHE INC. (US) 1994-06-21 US disclosed
EP-0475254-A1 Chlorophenyl-alkoxyalkyl-compounds F. HOFFMANN-LA ROCHE AG (CH) 1992-03-18 EP disclosed
EP-0433836-A2 Halophenyl substituted dioxanes F. HOFFMANN-LA ROCHE AG (CH) 1991-06-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250353824-A1 3-PHENYLPROPYLAMINE DERIVATIVE SF1, SF3A1, SFXN1 HTR3A 102/4885SLC2A1 3756/4885SLC18A3 2540/4885
US-12606533-B2 3-phenylpropylamine derivative SF3A1, SF1, HTR1D HTR3A 10/4885SLC2A1 1620/4885SLC18A3 2924/4885
US-20130267717-A1 PROCESS FOR THE PREPARATION OF ATOVAQUONE DHPS, VKORC1, DPYD HTR3A 3301/4885SLC2A1 2286/4885SLC18A3 1878/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.