Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 5/20 | 0.46 |
| ▸ | NOS3 | P29474 | 3/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.34 |
| ▸ | OTC | P00480 | 1/20 | 0.34 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL607060 | 1.00 | NOS1 (0.46) | NOS1NOS3NOS2MEN1KMT2A | |
| Nitroarginine SCHEMBL881062 | 0.88 | NOS1 (0.48) | NOS1NOS3NOS2OTCDDAH1 | |
| Nitroarginine SCHEMBL345312 | 0.88 | NOS1 (0.48) | NOS1NOS3NOS2OTCDDAH1 | |
| Nitroarginine SCHEMBL28365071 | 0.88 | NOS1 (0.48) | NOS1NOS3NOS2OTCDDAH1 | |
| L-Name SCHEMBL3034749 | 0.84 | NOS1 (0.41) | NOS1NOS3NOS2MEN1KMT2A | |
| L-Name SCHEMBL14751988 | 0.84 | NOS1 (0.41) | NOS1NOS3NOS2MEN1KMT2A | |
| L-Name SCHEMBL25310005 | 0.83 | NOS1 (0.40) | NOS1NOS3NOS2DPP7OTC | |
| L-Name SCHEMBL18812631 | 0.83 | NOS1 (0.40) | NOS1NOS3NOS2DPP7OTC | |
| SCHEMBL14123717 | 0.82 | NOS1 (0.48) | NOS1NOS3MEN1KMT2ATDP1 | |
| SCHEMBL608402 | 0.81 | NOS1 (0.49) | NOS1DPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102603781-A | Proteasome Inhibitors and Methods of Using the Same | CEPHALON INC | 2012-07-25 | — | — | CN | disclosed |
| CN-1867572-A | proteasome inhibitors and methods of use thereof | CEPHALON INC (US) | 2006-11-22 | — | — | CN | disclosed |
| EP-1658255-A2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005016859-A2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2005-02-24 | — | — | WO | disclosed |