Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | PPARG | P37231 | 5/20 | 0.41 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TSPO | P30536 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL5984748 | 0.97 | HSD11B1 (0.46) | HSD11B1FFAR1FFAR4KDM4EALDH1A1 | |
| SCHEMBL1333446 | 0.94 | HSD11B1 (0.49) | HSD11B1FFAR1FFAR4KDM4EALDH1A1 | |
| Bicarbonate SCHEMBL5984739 | 0.91 | HSD11B1 (0.47) | HSD11B1FFAR1FFAR4KDM4EALDH1A1 | |
| SCHEMBL1417730 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10PPARAPPARG | |
| SCHEMBL23519087 | 0.79 | NOTUM (0.48) | HSD11B1FFAR1FFAR4CYP1A2CYP3A4 | |
| SCHEMBL17186729 | 0.79 | KDM4E (0.49) | KDM4EALDH1A1HSD17B10PPARAPPARG | |
| SCHEMBL2432253 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10PPARAPPARG | |
| SCHEMBL16348228 | 0.77 | ACHE (0.55) | KDM4EALDH1A1HSD17B10PPARAPPARG | |
| SCHEMBL1331608 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1HSD17B10PPARAPPARG | |
| SCHEMBL7981702 | 0.77 | HSD11B1 (0.51) | HSD11B1FFAR1FFAR4ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660431-A2 | PHENOXYACETIC ACID DERIVATIVES | Astrazeneca AB (SE) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005018529-A2 | PHENOXIACETIC ACID DERIVATIVES | ASTRAZENECA AB (SE) | 2005-03-03 | — | — | WO | disclosed |