SCHEMBL598581

SCHEMBL598581

CC[C@H]1CC[C@H]2[C@@H]3CCC4CC(O)CC[C@]4(C)[C@H]3CC[C@]12C

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 4/20 0.69
GPBAR1 Q8TDU6 3/20 0.69
CYP3A4 P08684 2/20 0.69
SHBG P04278 1/20 0.69
SERPINA6 P08185 1/20 0.69
CYP1A2 P05177 1/20 0.69
CYP2C9 P11712 1/20 0.69
TSHR P16473 1/20 0.69
CYP2C19 P33261 1/20 0.69
HSD17B10 Q99714 1/20 0.69
GRIN1 Q05586 1/20 0.62
GRIN2B Q13224 1/20 0.62
GABRP O00591 2/20 0.61
GABRD O14764 2/20 0.61
G6PD P11413 2/20 0.61
GABRA1 P14867 2/20 0.61
GABRB1 P18505 2/20 0.61
GABRG2 P18507 2/20 0.61
GABRB3 P28472 2/20 0.61
GABRA5 P31644 2/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18891600 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL8074397 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL598580 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL7413090 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL7418009 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL14027906 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL14149787 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL3644724 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL2227935 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6
SCHEMBL6241057 1.00 LMNA (0.69) LMNAGPBAR1CYP3A4SHBGSERPINA6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025090435-A1 ALFAXALONE SYNTHESIS ZOETIS SERVICES LLC (US) 2025-05-01 WO disclosed
WO-2023060067-A1 AMORPHOUS SOLID DISPERSION GANAXOLONE FORMULATION MARINUS PHARMACEUTICALS, INC. (US) 2023-04-13 WO disclosed
US-11026953-B2 3-beta-hydroxy-5-alpha-pregnan-20-one for use in treatment of essential tremor ASARINA PHARMA AB (SE) 2021-06-08 US disclosed
US-11026954-B2 3-beta-hydroxy-5-alpha-pregnan-20-one for use in medical treatment ASARINA PHARMA AB (SE) 2021-06-08 US disclosed
US-20210161915-A1 GABA-A ANTAGONISTS FOR TREATING SUBSTANCE WITHDRAWAL DISORDERS ASARINA PHARMA APS (DK) 2021-06-03 US disclosed
WO-2021080880-A1 NMDAR INHIBITING AGENTS AND GABAAR POTENTIATING AGENTS AND USES THEREOF COVEY DOUGLAS (US) 2021-04-29 WO disclosed
EP-3773599-A1 GABA-A ANTAGONISTS FOR TREATING SUBSTANCE WITHDRAWAL DISORDERS Asarina Pharma ApS (DK) 2021-02-17 EP disclosed
WO-2019193138-A1 GABA-A ANTAGONISTS FOR TREATING SUBSTANCE WITHDRAWAL DISORDERS ASARINA PHARMA APS (DK) 2019-10-10 WO disclosed
WO-2018147792-A1 3-BETA-HYDROXY-5-ALPHA-PREGNAN-20-ONE FOR USE IN MEDICAL TREATMENT ASARINA PHARMA AB (SE) 2018-08-16 WO disclosed
WO-2018147791-A1 3-BETA-HYDROXY-5-ALPHA-PREGNAN-20-ONE FOR USE IN TREATMENT OF ESSENTIAL TREMOR ASARINA PHARMA AB (SE) 2018-08-16 WO disclosed
WO-2008154579-A1 ALLOPREGNANOLONE IN A METHOD FOR ENHANCING NEUROLOGICAL FUNCTION (ALZHEIMER DISEASE) UNIVERSITY OF SOUTHERN CALIFORNIA (US) 2008-12-18 WO disclosed
US-20080255076-A1 Steroid-Derived Pharmaceutical Compositions JADOLABS GMBH (DE) 2008-10-16 US disclosed
WO-2008063128-A1 THE USE OF PREGNANE AND ANDROSTANE STEROIDS FOR THE MANUFACTURE OF A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CNS DISORDERS UMECRINE AB (SE) 2008-05-29 WO disclosed
US-20080119416-A1 NEW STEROIDS HAVING INCREASED WATER SOLUBILITY AND RESISTANCE AGAINST METABOLISM, AND METHODS FOR THEIR PRODUCTION UMECRINE AB (SE) 2008-05-22 US disclosed
US-20080070876-A1 Gaba-Steroid Antagonists And Their Use For The Treatment Of Cns Disorders UMECRINE AB (SE) 2008-03-20 US disclosed
EP-1812009-A1 GABA-STEROID ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS Umecrine AB (SE) 2007-08-01 EP disclosed
EP-1789056-A1 USE OF STEROID-DERIVED PHARMACEUTICAL COMPOSITIONS FOR TREATING DISORDERS RELATING TO PATHOLOGICAL PROCESSES IN LIPID RAFTS Jado Technologies GmbH (DE) 2007-05-30 EP disclosed
WO-2006054938-A1 GABA-STEROID ANTAGONISTS AND THEIR USE FOR THE TREATMENT OF CNS DISORDERS UMECRINE AB (SE) 2006-05-26 WO disclosed
WO-2006002907-A1 USE OF STEROID-DERIVED PHARMACEUTICAL COMPOSITIONS FOR TREATING DISORDERS RELATING TO PATHOLOGICAL PROCESSES IN LIPID RAFTS JADOLABS GMBH (DE) 2006-01-12 WO disclosed
US-5439900-A Synergistic mixture of steroid and alcohol BUKUSOGLU CUNEYT (US) 1995-08-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080255076-A1 Steroid-Derived Pharmaceutical Compositions CYP11A1, CYP11B2, CYP11B1 LMNA 937/4885GPBAR1 56/4885CYP3A4 1919/4885
US-20080119416-A1 NEW STEROIDS HAVING INCREASED WATER SOLUBILITY AND RESISTANCE AGAINST METABOLISM, AND METHODS FOR THEIR PRODUCTION CYP21A2, CYP11B1, CYP11A1 LMNA 3230/4885GPBAR1 392/4885CYP3A4 103/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.