Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 5/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | GLS | O94925 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5988791 | 0.90 | KDM4E (0.40) | KDM4ELMNALCKKDM4ADYRK1A | |
| SCHEMBL5989058 | 0.87 | LCK (0.37) | KDM4ELMNALCKKDM4AGFER | |
| SCHEMBL5988925 | 0.85 | ALDH1A1 (0.41) | KDM4ELMNALCKKDM4ADYRK1A | |
| SCHEMBL24271761 | 0.85 | ALDH1A1 (0.41) | KDM4ELMNALCKKDM4A | |
| SCHEMBL5988910 | 0.84 | NPC1 (0.39) | KDM4ELMNALCKKDM4ADYRK1A | |
| SCHEMBL5989563 | 0.84 | CACNA1H (0.38) | KDM4ELMNAMAPKAPK2KDM4AGFER | |
| SCHEMBL24271886 | 0.82 | OPRM1 (0.43) | KDM4ELMNAKDM4AGFERCA1 | |
| SCHEMBL24271876 | 0.82 | MEN1 (0.40) | KDM4ELMNALCKKDM4ADYRK1A | |
| SCHEMBL8041513 | 0.82 | ALDH1A1 (0.48) | KDM4ELMNA | |
| SCHEMBL5988095 | 0.80 | KDM4E (0.41) | KDM4ELMNAKDM4AGFERDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7144902-B1 | Prodrugs of thrombin inhibitors | ABBOTT GMBH & CO. KG (DE) | 2006-12-05 | — | — | US | disclosed |
| US-6740647-B1 | AMIDINES AND HYDROXYAMIDINE DERIVATIVES | ABBOTT GMBH & CO., KG (DE) | 2004-05-25 | — | — | US | disclosed |
| EP-1051431-A1 | THROMBIN INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 2000-11-15 | — | — | EP | disclosed |
| WO-1999037668-A1 | THROMBIN INHIBITORS | BASF AKTIENGESELLSCHAFT (DE) | 1999-07-29 | — | — | WO | disclosed |