Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | F2R | P25116 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.42 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3969336 | 0.87 | SMN1; SMN2 (0.54) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3050248 | 0.84 | ALDH1A1 (0.72) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5990487 | 0.84 | ALDH1A1 (0.63) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL5994455 | 0.82 | ALDH1A1 (0.53) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3055459 | 0.81 | RAB9A (0.49) | ALDH1A1LMNAF2RRAB9ASMN1; SMN2 | |
| SCHEMBL5988040 | 0.80 | NPC1 (0.49) | ALDH1A1LMNAF2RRAB9ASMN1; SMN2 | |
| SCHEMBL3059121 | 0.79 | KMT2A (0.56) | ALDH1A1LMNARAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3064657 | 0.79 | LRRK2 (0.49) | LMNAF2RRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL3054663 | 0.79 | PARP1 (0.50) | ALDH1A1LMNAF2RSMN1; SMN2HPGD | |
| SCHEMBL3059887 | 0.79 | RAB9A (0.53) | ALDH1A1F2RRAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1673360-A1 | FURAN DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ASTERAND UK LIMITED (GB) | 2006-06-28 | — | — | EP | disclosed |
| WO-2005037812-A1 | FURAN DERIVATIVES AS EP4 RECEPTOR ANTAGONISTS | ASTERAND UK LIMITED (GB) | 2005-04-28 | — | — | WO | disclosed |