Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | HTR6 | P50406 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30166149 | 1.00 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3HTR2AHTR2C | |
| SCHEMBL9963337 | 0.86 | KDM4E (0.47) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL2268086 | 0.79 | KDM4E (0.44) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL2268143 | 0.79 | KDM4E (0.44) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL2268137 | 0.79 | KDM4E (0.44) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL9727950 | 0.79 | KDM4E (0.44) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL2268091 | 0.79 | KDM4E (0.44) | KDM4EGAAPDPK1CYP3A4CYP1A2 | |
| SCHEMBL905990 | 0.78 | PDPK1 (0.54) | HTR2AHTR2CHTR1AHTR1DHTR1B | |
| SCHEMBL2553028 | 0.78 | HTR2C (0.48) | SLC6A2HTR2AHTR2CHTR1AHTR1D | |
| SCHEMBL5987890 | 0.78 | HTR2A (0.55) | SLC6A2SLC6A4HTR2AHTR2CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060052431-A1 | 5-Hydroxy indazole derivatives for treating glaucoma | MAY JESSE A | 2006-03-09 | — | — | US | disclosed |
| US-7005443-B1 | 5-Hydroxy indazole derivatives for treating glaucoma | ALCON, INC. (CH) | 2006-02-28 | — | — | US | disclosed |
| CN-1450995-A | 5-hydroxy indazole derivatives for treating glaucoma | ALCON AG (CH) | 2003-10-22 | — | — | CN | disclosed |
| EP-1268439-A1 | 5-HYDROXY INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | Alcon Inc. (CH) | 2003-01-02 | — | — | EP | disclosed |
| WO-2001070701-A1 | 5-HYDROXY INDAZOLE DERIVATIVES FOR TREATING GLAUCOMA | ALCON, INC. (CH) | 2001-09-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060052431-A1 | 5-Hydroxy indazole derivatives for treating glaucoma | PTGIS, PTGIR, PDE3A | SLC6A2 3544/4885SLC6A4 2369/4885SLC6A3 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.