Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 4/20 | 0.41 |
| ▸ | PPARD | Q03181 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5990096 | 0.83 | LMNA (0.42) | LMNAGAASMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL5991233 | 0.78 | PPARG (0.56) | LMNAATMMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL30785075 | 0.78 | PPARG (0.56) | LMNAATMMAPTSMN1; SMN2NPSR1 | |
| SCHEMBL5989871 | 0.78 | CDC25B (0.56) | — | |
| SCHEMBL5989236 | 0.78 | PPARA (0.52) | MAPTNPSR1PPARAPPARDPPARG | |
| SCHEMBL5989823 | 0.78 | PPARA (0.52) | MAOBLMNAMAPTSMN1; SMN2HSD17B10 | |
| SCHEMBL5991276 | 0.76 | CTNNB1 (0.51) | LMNAGAAMAPTSMN1; SMN2NPC1 | |
| SCHEMBL18650496 | 0.75 | KCNK3 (0.36) | LMNAGAASMN1; SMN2KCNK3KCNK9 | |
| SCHEMBL9726523 | 0.75 | NPC1 (0.56) | LMNAATMGAAMAPTSMN1; SMN2 | |
| SCHEMBL12013165 | 0.74 | S1PR1 (0.46) | GAAS1PR1PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |