Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.46 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 7/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5992333 | 0.91 | LOXL2 (0.54) | POLBLOXL2CYP19A1CRHBPCRHR2 | |
| SCHEMBL9737481 | 0.87 | AOC3 (0.45) | MAOBCNR1HTT | |
| Hydrochloric Acid SCHEMBL9518394 | 0.85 | AOC3 (0.44) | MAOBCNR1HTT | |
| SCHEMBL5991679 | 0.83 | CYP19A1 (0.58) | MAOAMAOBLOXL2CYP19A1CRHBP | |
| SCHEMBL5991160 | 0.83 | CYP2A6 (0.55) | KDM1ALOXL2CYP19A1CRHBPCRHR2 | |
| SCHEMBL5990594 | 0.83 | NSD2 (0.52) | MAOAMAOBKDM1ALOXL2CYP19A1 | |
| SCHEMBL5991320 | 0.83 | CYP19A1 (0.58) | MAOAMAOBLOXL2CYP19A1CRHBP | |
| SCHEMBL5992560 | 0.82 | MEN1 (0.53) | MAOAMAOBPOLBKDM1ALOXL2 | |
| Hydrochloric Acid SCHEMBL28901400 | 0.81 | CRHBP (0.58) | MAOAMAOBPOLBLOXL2CYP19A1 | |
| SCHEMBL5991163 | 0.79 | MAOA (0.54) | MAOAMAOBPOLBLOXL2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1572665-B1 | 1-N-PHENYLAMINO-1H-IMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | THERAMEX (MC) | 2006-05-03 | — | — | EP | disclosed |
| EP-1572665-A2 | 1-N-PHENYLAMINO-1H-IMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | LABORATOIRE THERAMEX (MC) | 2005-09-14 | — | — | EP | disclosed |
| WO-2004054983-A2 | 1-N-PHENYLAMINO-1H-IMIDAZOLE DERIVATIVES AS AROMATASE INHIBITORS | LABORATOIRE THERAMEX (MC) | 2004-07-01 | — | — | WO | disclosed |
| EP-1431292-A1 | 1-N-phenylamino-1H-imidazole derivatives as aromatase inhibitors | LABORATOIRE THERAMEX (MC) | 2004-06-23 | — | — | EP | disclosed |
| US-6737433-B1 | ESTROGEN DEPENDENT ANTITUMOR AGENTS | LABORATOIRE THERAMEX (MC) | 2004-05-18 | — | — | US | disclosed |