Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.32 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL297153 | 0.76 | — | — | |
| Tromethamine SCHEMBL11284325 | 0.74 | MEN1 (0.46) | MEN1LMNAKMT2ALOXLOXL3 | |
| Hydrochloric Acid SCHEMBL28881411 | 0.73 | — | — | |
| Hydrochloric Acid SCHEMBL23362774 | 0.73 | — | — | |
| Bromide SCHEMBL11219310 | 0.73 | — | — | |
| Tromethamine SCHEMBL680918 | 0.72 | — | — | |
| Tromethamine SCHEMBL9298764 | 0.72 | — | — | |
| Tromethamine SCHEMBL9718986 | 0.71 | MEN1 (0.42) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL6143310 | 0.71 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL2943158 | 0.70 | MEN1 (0.71) | MEN1LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7045531-B1 | Composition comprising a metal chelator and a method of treating amyloidosis by administering the metal chelator | THE GENERAL HOSPITAL CORPORATION (US) | 2006-05-16 | — | — | US | disclosed |