Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11508040 | 0.79 | — | — | |
| SCHEMBL7815850 | 0.79 | — | — | |
| Tromethamine SCHEMBL5990767 | 0.71 | MEN1 (0.48) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL11284325 | 0.70 | MEN1 (0.46) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL9298764 | 0.68 | — | — | |
| Tromethamine SCHEMBL680918 | 0.68 | — | — | |
| Tromethamine SCHEMBL6143310 | 0.66 | MEN1 (0.62) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL27944889 | 0.65 | MEN1 (0.83) | MEN1LMNAKMT2A | |
| Tromethamine SCHEMBL975 | 0.65 | — | — | |
| Tromethamine SCHEMBL3696191 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0472230-A2 | Flame retardant polyamides | DSM N.V. (NL) | 1992-02-26 | — | — | EP | disclosed |
| US-5071894-A | Iron compound; char forming aromatic thermoplastic polymer; non-corrosive, non-degrading additive | STAMICARBON B.V. (NL) | 1991-12-10 | — | — | US | disclosed |