Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.44 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27447653 | 0.86 | SLC6A2 (0.47) | SLC6A4HTR1ASLC6A2SLC6A3USP2 | |
| SCHEMBL5989716 | 0.81 | HTR2C (0.48) | PTGER4SLC6A4HTR2AKCNH2L3MBTL1 | |
| SCHEMBL4514958 | 0.81 | CYP1A2 (0.58) | SMN1; SMN2CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL5989737 | 0.81 | L3MBTL1 (0.63) | SLC6A4MRGPRX4HTR2AKCNH2L3MBTL1 | |
| SCHEMBL4338407 | 0.80 | SLC6A4 (0.50) | SLC6A4HTR2AHTR1ASLC6A2SLC6A3 | |
| SCHEMBL5989471 | 0.77 | LMNA (0.42) | PTGER4PTGER2SLC6A4MRGPRX4HTR2A | |
| SCHEMBL11296580 | 0.77 | HPGD (0.53) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL9467645 | 0.77 | FFAR1 (0.45) | SLC6A4KCNH2SLC6A2SLC6A3 | |
| SCHEMBL20034248 | 0.77 | SLC6A2 (0.43) | SLC6A4HTR1ASLC6A2SLC6A3USP2 | |
| SCHEMBL4447285 | 0.76 | PTGER4 (0.62) | PTGER4PTGER2MRGPRX4L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060257987-A1 | Ppar modulators | ELI LILLY AND COMPANY | 2006-11-16 | — | — | US | disclosed |
| EP-1660428-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005019151-A1 | PPAR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-03 | — | — | WO | disclosed |